i got 23andme for my whole family years ago when they gave out health risks. now they just do ancestral stuff i think, but you can pay $5 to promethease and send your raw genetic data for their analysis.
i found i have several snps associated with type 2 diabetes in the gene TCF7L2. from wikipedia:
“The single nucleotide polymorphism (SNP) within the TCF7L2 gene, rs7903146, is, to date, the most significant genetic marker associated with Type 2 diabetes mellitus (T2DM) risk. SNPs in this gene are linked to higher risk to develop type 2 diabetes, as well as gestational diabetes.”
i don’t have the alzheimer’s gene apoe4, but i do have the progranulin defect, which is associated with an early onset dementia called frontotemporal lobe dementia, or ftd.
i stopped coming to tudiabetes after i found out i had that defect, and i was a basket case for several months. then i emailed a researcher of ftd, and she told me that defect is in 20% of the population. apparently there are some other genes or other triggers in the environment that have to be present with my defect in order for the dementia to surface. my husband is also heterozygous for that defect, and one of my daughters is homozygous, which is even rarer. so i was freaking out.
now i have calmed down a bit, but i am more serious about researching potential triggers. anesthesia is thought to be a possible trigger to ftd and alz in those genetically predisposed, so if i need a surgery, i may get an epidural, or something like that, instead of general anesthesia. i also take no anticholinergic medications, which are very common (ie benadryl, etc).
so just finding out about ancestry is not upsetting, but finding out about potential health risks, particularly when there is no treatment, can make you go nutty. all in all, i’m more motivated to try to enjoy the moment and take care of my health at the same time, so i’m glad i put my raw genetic data through promethease. just know that if you go beyond ancestry, you could be opening up a pandora’s box of worry.