I have LADA, dx 1/1/16 and have been using Afrezza for about 4-5 months. In the beginning I needed to increase Tresiba basal, but now I’ve needed to decrease dramatically because of severe nighttime lows. The last few weeks I’ve been eating most of the night and last night was in the 30’s even after eating a ton of fruit. I am insulin-sensitive and have decreased my basal starting from 7 units until yesterday was down to 3 units. Today I discontinued Tresiba and will use Levemir 2 or 3 units at night and none during the day. Levemir is supposed to clear in about 12 hours.
Also, when I first started using Afrezza I needed to make 2 unit cartridges to accommodate my insulin sensitivity. Now, I use the 8 unit cartridges routinely and no longer need 2 units. The onset isn’t as fast either. It is still relatively quick, but not like it was.
Of note, my A1c last week was 5.4!!! Decreased from 6.6.
Does anyone have similar experience? Does anyone have literature to explain? The decreased basal requirement makes me excited to think that maybe some beta cells are kicking into gear. I also wonder, if somehow, the Afrezza is having a delayed effect. Especially since my sensitivity to it has changed compared to when I first started using slight_smile: I am very sensitive to the side-effects of high blood sugar so I treat aggressively to avoid going high. I wonder if the decease in Afrezza sensitivity is actually Afrezza-storing for slow release later… as if it were fat soluable. Instead of Afrezza clearing in 90 minutes as it appeared to in the beginning, it is clearing much more slowly.