Disconnect during take off and landing?

No No Noooooo - fly all the time - if this were a thing - there would be literature on it from the manufacturers.

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Some people have troubles with sugar levels just from traveling - time zones, changes in eating patterns and foods. I won’t say that it isn’t possible, but I would be thinking something else is much more likely.

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I to travel a lot and have for years. I find that pretty much everything about air travel is likely to mess with blood sugars to some extent: time zone changes, getting up early to make it to the airport, being tired, airport food, stress…
I doubt that the cabin pressure change is any worse that any of that. I recommend watching your CGM or checking regularly while your flying and just rolling with the chaos.

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Only thing I’ve experienced is when I travel to Ohio from Florida. Going from sea level to higher elevations, your body works harder to breath, thus, don’t need as much basal for a week or two until your body adjusts. No effects for me when I fly back to Florida.

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