G6PD - something else you haven't heard of

What is G6PD and why should a KPD care? Well, it’s another one of your problems and it may be the reason why KPD’s should be wary of carbohydrates.

G6PD is an enzyme that helps in the breakdown of carbohydrates. If it isn’t present then certain pathways that deal with glucose metabolism aren’t activated. There’s a lot more to it but the short form is that glucose is a bad actor and this helps keep it contained. You more than likely are deficient here. This shouldn’t be a great surprise since this is the most common deficiency in humans.



Currently, there are 200 million people worldwide with red cell x-linked chromosome defects who, with the persistent ingestion of refined carbohydrates, are at greater risk of developing hypertension or diabetes mellitus...

What has been found is that KPD's are far more likely to have G6PD deficiency than other diabetics. You could view it as a marker for KPD.

High Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency without Gene Mutation Suggests a Novel Genetic Mechanism Predisposing to Ketosis-Prone Diabetes http://jcem.endojournals.org/cgi/content/abstract/90/8/4446

The prevalence of G6PD deficiency was higher in KPD than in T2DM and controls (42.3%; 16.9%; 16.4%; P = 0.01). In KPD, but not in T2DM, insulin deficiency was proportional to the decreased G6PD activity (r = 0.33; P = 0.04).

42% to 17% that's big. What I find interesting is that insulin deficiency was proportionate to decreased G6PD activity. The other really important part is that, for the most part, there was NO gene mutations beyond regular type 2's can controls. So we are looking at a difference of about 20% that comes from some where but it isn't genetic.This, however, was done on a West African population so it could be a bit skewed.



Hi Scott
KPD stands for Ketosis Prone Type 2 Diabetic. It’s type 2 that starts out like a type 1. We are the type 2’s that can easily go DKA.