I can present a sample of some research on this topic for your consideration:
A. Pena, et al., “Hypoglycemia, But Not Glucose Variability, Relates to Vascular Function in Children with Type 1 Diabetes,” Diabetes, Technology, and Therapeutics, 14 (6) 457-462: “Hypoglycemia, but not glucose variability … relates to impaired vascular endothelial function in children with type 1 diabetes.”
M. Gimenez, et al., “Repeated Episodes of Hypoglycemia as a Potential Aggravating Factor for Preclinical Atherosclerosis in Subjects with Type 1 Diabetes,” Diabetes Care, 34 (1) 1980203 (2011): “… repeated episodes of hypoglycemia could be related to and considered an aggravating factor for preclinical atherosclerosis in type 1 diabetes. The precise mechanisms explaining this association remain to be clarified.”
A. Sheen, “Central Nervous System: A Conductor Orchestrating Metabolic Regulations Harmed by Both Hyperglycaemia and Hypoglycaemia,” Diabetes and Metabolism, Supplement 3, S31-S38 (2010): “… the brain is mainly a glucose-dependent organ, which can be damaged both by hypoglycaemia and hyperglycaemia.”
J. Snell-Bergeon and R. Wadwa, “Hypoglycemia, Diabetes, and Cardiovascular Disease,” Diabetes, Technology, and Therapeutics, Supplement S51-S58 (2012):“There is evidence that hypoglycemia may adversely affect cardiovascular risk in patients with diabetes … . Hypoglycemia causes a cascade of physiologic effects and may induce oxidative stress and cardiac arrhythmias, contribute to cardiac death, and cause ischemic cerebral damage … .”
D. Oyer, “The Science of Hypoglycemia in Patients with Diabetes,” Current Diabetes Reviews, 9 (3) 195-208 (2013): “Long-term effects of severe hypoglycemia, aside from causing accidents, may include adverse cardiovascular outcomes and cognitive impairment.”
H, Snell-Bergeon and K. Nadeau, “Cardiovascular Disease Risk in Young People with Type 1 Diabetes,” Journal of Cardiovascular Translational Research, 5 (4) 446-462 (2012): “This review discusses the risk factors for CVD [cardiovascular disease] for people with T1D [type 1 diabetes], including hyperglycemia …, as well as novel risk factors such as insulin resistance, inflammation, and hypoglycemia.”