Im 20 years old, obese, and insulin resistant. Does that mean that Im diabetic or going to be diabetic?

To give you some background Im 20 years old and all my life ive basically been the posterchild for childhood obesity. I cant remember a time that I wasnt chubby and I know that I became medically obese around elementary school. I weighed 212 lbs (size 16 womens) in 7th grade and hit my heighest weight of 252.5 lbs (size 21) when I was 16. Right now I am 218 lbs (size 16).

I always knew I had hormone problems because I went about a year without getting my period back when I was 14 and I went to the gynecologist and they gave me birth control pills to fix it. Eventually when I was 19 I started feeling more and more unhealthy and begged my mom to take me to the endocrinologist. After running some blood tests and checking my thyroid, the doctor came to the conclusion that I am insulin resistant. She prescribed me 1000mg of metformin a day and told me not to eat starchy foods. In the past six months of taking metformin and eating much healthier and exercising around 75% of the time I was lost 14 lbs.

Ive been doing research on the internet and s ome of the questions that I have got conflicting answers to are

  1. is insulin resistance the same as type 2 diabetes?
  2. does being insulin resistant guarantee that one day I will be full blown diabetic?
  3. how much can i reverse all of these problems by losing weight?
  4. should I be monitoring my blood sugar?
  5. should I be eating low carb or just whole, complex carbs in normal amounts?

Sorry for asking so many questions, Im just kind of confused and this website seems like such a great place to info. Thank you all.

–Jessica

  1. Insulin resistance is something commonly associated with developing type 2, but no, it’s not the same. You can be insulin resistant and not have diabetes.
  2. No, but it does increase your odds.
  3. A lot - being heavier increases your insulin resistance (for diabetics and non-diabetics), plus losing weight has a lot of other health benefits other than reducing your risk for diabetes.
  4. If your bloodwork has all been normal, probably not… if you are concerned you should be, that’s probably something to ask your doctor. Ask them for copies of your lab work as well so you can know for sure what your results are.
  5. This I’m not sure 100% about… I would think a normal “balanced” calorie-restricted diet while you are trying to lose weight would be fine… I wouldn’t think necessarily that low-carb is a must for you right now. Avoiding refined sugar/juice is a good idea for anyone though simply because it’s usually little more than excess calories (you don’t have to cut out fruit - whole fruit is loads better for you than fruit juice is). Any time you have the option to choose something made from whole grains or with extra fiber (such as wheat bread vs white bread, brown rice vs white, etc) you probably should.

Thanks you guys. I have been exercising doing the elliptical for about 30 minutes about 4 times a week. I also eat pretty much all whole grains. I dont really eat the refined, white carbs unless Im actually having a slip up and eating a cupcake or something, which happens very seldomly. My doctor never said anything about checking my blood sugar, but I know that sometimes doctors dont tell you everything you really need to hear so Ive been trying to find some kind of consensus as to whether I am at that level yet.

Insulin resistance is not the same thing as diabetes, and does not inevitably lead to it. There is evidence that people who are overweight and insulin resistant, but do not have the genes for diabetes, will simply make more beta cells, and will successfully make more insulin to keep up with the insulin resistance. People with diabetes genes, conversely, seem to lose beta cell mass; there are some theories that at least one possible cause is that there’s a defect in the beta cells which, when they attempt to divide and thus create more cells as a normal person’s cells would do, the cells instead die, so that person ends up with fewer instead of more.

It’s not a bad idea to monitor your blood sugar, because obviously there are strong correlations, even if there’s not causation, between obesity and type 2 diabetes. Your doctor has probably looked at fasting glucose, but fasting glucose can still be okay for years after post-meal glucose starts to go out of bounds, so the post-meal numbers are the ones I’d look at. Get yourself a meter (Wal-Mart sells one, under the ReliOn brand, that’s $9 for the meter and $9 for a box of 20 test strips, and it’s about as reliable as the more expensive models), and eat something like a bagel (no cream cheese, or at least fat-free cream cheese, because fat slows down carb absorption), and then test your blood sugar at 1 hour and 2 hours after. A non-diabetic will register under 140mg/dL at 1 hour, and under 120 at 2 hours; if your numbers are slightly higher but close to that, I wouldn’t be terribly concerned, although I’d check it again in a few months, but if they’re significantly higher, then I’d go back to your doctor and insist on a glucose tolerance test.

To the extent your insulin resistance is caused by your weight (and excess weight can cause it, although it’s not the only cause), then losing the weight should significantly improve it. However, it’s really hard to lose the weight if your system is drenched in insulin all the time – one of insulin’s jobs is to move triglycerides into fat cells, and keep them there, so it’s difficult to get the fat to come out and be burned in a high-insulin environment. That’s where low-carb comes in; by keeping your carbs down and your protein moderate, you avoid calling for your pancreas to produce large amounts of insulin in the first place, and this makes it easier to mobilize the fat you’ve already got for energy. I would keep all carbs low, and get the carbs you do eat from things like leafy or cruciferous vegetables primarily, with a little bit of lower-carb fruits like berries and melon; the supposedly healthy complex carbs still break down to the simple sugars (glucose and fructose) before they’re metabolized, so they still require the same metabolic processes. Yes, you get more B vitamins and such from whole wheat bread than from Hostess cupcakes, but ultimately all the carbs in both turn into sugar, so you’re still going to cause significant issues with the bread; I would leave it alone until you get at least close to your goal weight – once you’ve lost the weight, you can be more liberal with your carbs, and adding back in carbs that are good sources of nutrients is better than adding back ones that aren’t.

I’m going to suggest some recommended reading and viewing. First, Jenny’s site, Blood Sugar 101, is great for bringing together the science about diabetes; you can see there that she lays out much of the information I conveyed above about how diabetes gets started. Second, Tom Naughton’s DVD documentary, “Fat Head,” is a great introduction to the science of low-carb, and entertaining besides. I also recommend Gary Taubes’ book, “Good Calories, Bad Calories” – it covers the science much more fully, although it’s a pretty dense read. And finally, I’ll recommend “Protein Power” by Drs. Michael and Mary Dan Eades; they lay out a low-carb eating plan, but they also talk a lot about the roles of insulin in the body, which I found really helpful.

Good luck to you!

Hey Jessica it sounds like a tough situation. First I want to second what sara mentioned about doing an after meal glucose test. She is right that your fasting will be in a normal range a lot longer than your post meal glucose. Doing a true OGGTT or post prandial glucose test will catch any diabetes faster as IGT happens much quicker to the body than IFG. Second I want to point out that metformin, although the best drug to treat any type two related symptom will not really address your insulin resistance completely. Its product label states only that it is an insulin sensitizer and in fact will address insulin resistance only in your liver. Its primary mechanism of action is to blunt gluconeogenesis or production of glucose by the liver (happens in the fasting state when you are hungry or when glucagon is high). The fact is that 80% of your sugar is taken up by your muscle cells and if they are insulin resistant then metformin really won’t address this. Right now your pancreas is probably fighting to keep up with the insulin demands needed to overcome the resistance at your cellular level and although some respondents think some people can create new beta cell volume most adults cannot. As such your beta cells in the pancreas will eventually start to burn out, your insulin production will drop from its current levels and you will become diabetic. I would think your best bet is regular vigorous exercise (as determined by your MD) and dietary modification including carb reduction; also do the OGGTT test and maybe get a baseline c-peptide to see what kind of insulin your pancreas is currently pumping out.