Reading thru the chemistry of cell physiology and reviewing my own type 2 experiences raises a host of questions and confusions.
Current thinking on glucose control starts with glucose generation and ends with insulin – just add more.
Interestingly, the skeletal muscle cells can draw glucose directly from the blood stream when the cell’s local glucose cell stores are exhausted regardless if insulin operation is impaired. Want to get your BG down, exercise hard till local stores exhausted and BG starts down. Skeletal cells can draw a huge amount of glucose under these circumstances. I have found same walking 2 miles around my condo park reliably. Adding more insulin and if fat cells and skeletal muscle cells have room will cause glucose to move to local stores of fat and skeletal muscle cells, only hearty exercise gets the glucose burned out.
According to theory; the fat cells and skeletal muscle cells constitute the bulk of the cells that rely on insulin to store/regulate the extra glucose in the blood system by using insulin to transfer glucose into those cells. Some suggest that when local store of these cells is full, the cells will turn off glucose transfer by turning off the insulin attempting to push extra glucose into cell to prevent cell damage due to excess glucose. That sounds like insulin resistance to me. The cells get saved but the body destroys itself with glucose backed up.
If the fat cells and skeletal muscle cells are key to regulating the glucose of the Blood stream by storing more glucose on command; how does this regulation work when the liver, fat and skeletal muscle cells are fully loaded
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The human body and its fat and muscle cells are not a infinite glucose dump. So how does the body regulate glucose levels when liver and these cells become fully loaded.
I find that daily hearty exercise and overall carbs control is critical to keeping better BG numbers along with meds for needed shortcomings and deficiencies.
Today’s plentiful grain and food operations in land of plenty and dramatic reduction of exercise suggests that there will be an excess of glucose backing up in a body leading to excess weight and type 2 diabetes.
The fat cells and the skeletal muscle cells can only store so much and it is only logical that cells would defend themselves against too much glucose being transferred into them and would have capability to shut off glucose transfer into cell by turning insulin off.
The human body grabs every calorie that is loaded into gut and does not throw away excess. If it did or had a reduced controllable absorption intestine, than the body would shut off calorie absorption when the liver, fat cells and skeletal muscle cells are full preventing the backup of glucose and resulting out of margin bg readings. Since the body does not control glucose absorption at gut/intestine level ,external calorie input control and hearty exercise are needed on daily basis to keep the storage elements sufficiently unloaded so body can regulate glucose levels using insulin continuously.
I believe current thinking and attitude are suffering from incomplete stories, and abbreviated simplifications that ignore critical cell operation and overall glucose flow, control and final consumption/conversion to reduction components for exhaust from system and the drawing down of the glucose storage parts in fat and skeletal muscle cells.
Failure to consider all these aspects prevents one from failing to get complete control of Type 2 insulin resistant diabetes and properly controlling and implementing necessary calorie control as well as sufficient hearty exercise crucial with any needed meds tuning corrections