Insulin resistance is response of muscle cells to block insulin forcing in extra glucose on cells already overloaded

Type 2
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I have found study that claims that insulin resistance is response of a muscle cell already overloaded to glucose that shuts off the insulin to block any further transfer of insulin.

I believe this makes very rational sense and have seen with personnal experience whereby when cells loaded up, BG will not drop below 180 regardless of amount of insulin. Walk 2 miles and BG starts dropping fast and insulin becomes very responsive again.

I saw this every day due to liver overloading glucose on dawn effect every day from 3:00 am thru 6:00 am
and BG rammed up to 238. Walk 2 miles, BG drops back to normal as insulin goes back to work. During this cycle a1c was 13.3.

Using netformin doses properly timed would stop this dawn effect nonsense and see midnight bg of 122 to 130 and morning wakeup of 122 to 130 with full insulin sensitivity ( as best as I have ever seen)
Prior to metformin change 26 units of 75/25 would not bring down BG until I walked 2 miles.
After issue and using humalog lispro, only 4 units needed in am and worked great and a1c is 6.4.

This is why energy control/burn versus energy input must match up to prevent overloading the muscle cells and turning on insulin resistance. The land of plenty and massive couch potato games, entertainment and lap top tools and automobiles are making this problem worse!

Its not that any one meal is an issue, but constant overloading the muscle cells ends up at point where no more room and the BG climbs. Human body was never optimized for land of plenty and min exercise.
Quite the reverse, most of us have body’s optimized for when food was scarce and scrawny and the body optimized to prevent staravation.
3886-InsulinResistanceStopsSuperoxideStress.doc (45 KB)

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Interesting article Jims. I hear what you are saying… it takes a massive amount of exercise to control blood sugar levels for some of us with insulin resistance. I walk every day and take a different exercise class four nights a week. At home I use weights and the exercise ball. I have done this for years… long before my diagnosis. Still… while I know it works, I have no idea why. I find that each new article confuses me more.

I am currently experiencing rapid weight loss… a lot faster than I would like because I am not healthy. If I decrease the exercise the sugar will go up. It’s all just so difficult! Have you found the injected insulin gives you a better chance with the sugar control?

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You ask many good questions and make excellent points.



The reason for the confusion is simple and legit as science/meds are investigating parts of this and cell operation but unfortunately much of what is being done is all over map and does not fit the current orthodoxy so ignored nor advanced.
In addition, storage capabilty of the skeletal muscles of glucose is
ten times that of liver.


In my case , what was amazing is the sharp cut-off of how much exercise it took to see effect.

I had 1/4 mile loop I walked and reliably noticed:

6 loops and under, dam problem stayed stuck on, Walk 2 more loops and bg would start dropping dramatically
and thunder down.

Many times, I did not have time to walk more than 6 loops and BG stayed stuck up for 2 hours and would not budge
till the last 2 loops walked. This was repeatable every dam morning.

The body hystersis is pain in but. Also, brfeakfast and eating in am makes problem worse, I found that it was critical to have super low glycemic snack/breakfast to minimize fresh carb load to body. Sure as heck, walking increases the
gut/intestine glucose output. Skip all grains, carbs etc in am. By lunch my body stabalized and no longer issue.

I got fed up with this crap that led to search for something that would stop liver in tracks.

By mistake and web comments, I found by shere chance taking standard met late at night knocked back the morning bg.

With my Doctor and experimenting with 500 mg doses of standard met; I found that a dose at 10:00pm and one at 12:00am midnight would shut down this dawn effect completely from midnight to 6:00 am.

Large single doses of metformin DO NOT WORK< Met ER and Teva useless. Most generics work.

Effect depends on met up to strength in Blood stream while met is up to full force. Once it leaves body, liver goes back to over sugaring mode. Residual met buildup has no bearing whatsoever.

Today; I run diet of 1200 calories and continue to walk 1 to 2 miles and find that have good bg numbers and a1c is 6.4.
It took about 6 monthe to scarf up excess glucose laying around body and get it back to operating better.

Medicine has head where sun does not shine over the whole glucose flow , insulin resistance issue, and badly understood nor need for energy balance thinking to ensure glucose levels in skeletal muscles do not max out the storage and back up the body bg - diabetes and rot out body.


See john hopkins and salk institute for articles on effects of metformin on liver. Most of industry asleep on issue.



The liver’s power to add glucose when not really needed is extremely powerful, pain in ■■■ that most medicin assumes is minor inconvenience. Terribly wrong, mis-guided, off track useless thinking.



I will get link to the research article.

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link is:

www.suite101.com/content/insulin-resistance-stops-superoxide-stress-a172225

Hope this helps

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So why does exercise bring your blood sugar down? Yes, exercise depletes glycogen reserves, leaving a gap that gets filled, but exercise also dramatically increases insulin sensitivity (through increased levels of GLUT-4). And you pose an interesting question, even in non-diabetics, once you have filled your glycogen stores, where does all the extra glucose go? The best I can tell is that it is converted to triglycerides and becomes bodyfat. But the processes that make the switchover do not make you insulin resistant, they simply enable the shunting of glucose through different processes.

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Well, all I know is If you can’t keep the BG’s At or Below 140? You better take medications and then Onto Insulin and Get the BG’s Under control FIRST and then work on everything else…2nd…

Test your BG’s B4 Eating and then 2 hrs after Eating, Bedtime, 4 hrs after Bedtime and When you get up anytime it’s above 140? Not a Good Sign…

Got the books?
Dr. Bernsteins-Diabetic Solutions
If using Insulin- THINK LIKE A PANCREASE

7

Dennis:



Yes from an operational aspext , the points you mention is where a type 2 needs to operate at.



The point of my article and I apologize I did not make this clear:



It is critical to keep glucose marching out of body and ensure room at all times for more glucose in skeletal muscle cells

to absorb more glucose at all times or face fact that one will NOT be able to maintain the numbers you mention and one will have to force body skeletal muscle cells to accept more glucose by use of actos and increased insulin injections.



Keeping skeletal muscle cells partially empty of glucose by exercise is crucial to maintain the numbers you mention or face body rot and increased BG numbers, more insulin and that charmer actos/avendia.



Its your call. One does have choices. Exercise and manage energy input and save one’s body.