Molecular mechanism of Type-1 identified?

It looks like there is strong evidence suggesting that a particular mutation on a HLA gene leads to a change in the protein molecule resulting in T-cells enriched that cause autoimmunity. The authors also think this could provide clues for a cure. An excerpt:

Now, in the new study the researchers found that diabetes-causing mutations changed the charge at one end of the MHC peptide-binding
groove. In individuals not predisposed to type 1diabetes, MHC molecules

usually have a negatively charged residue at position 57. In contrast,

disease-causing MHC molecules have a neutral residue at position 57 and

consequently the surrounding region is more positively charged.

The result of this molecular change was that the mutated MHC molecules
selected a unique subset of T cells that bound to it strongly, with
“higher affinity.” These T cells may overreact and potentially

misidentify “self” peptides as dangerous rather than harmless.





More here:http://esciencenews.com/articles/2010/04/19/scripps.research.scientists.reveal.how.genetic.mutations.may.cause.type.1.diabetes





I’ve seen stuff about position 57 before.
http://diabetes.diabetesjournals.org/content/47/12/1971.full.pdf

Don’t know if that helps??

Thanks, Kathy. That did help.

I’m cautious about getting hopes up because they’re usually dashed, but this sounds encouraging.