My endo at GW hospital in DC was also a big researcher. He told me straight out that Lantus will not work effectively as a basal for a whole 24 hours and should be split into two doses for a more stable blood glucose level all day and night. I dosed like that for years--it was one of the main reasons I went to a pump--too many shots.
Yes, when I was on Lantus I had to inject it twice per day as well. It only seemed to last about 20 hours for me otherwise and I had extreme highs during the time it "wore off."
I'm terrified. I was diagnosed as Type 2 a few years ago but it seems now that my pills are not working. They think my high blood sugars have ruined my beta cells. Now they are experimenting with Lantus. My fasting blood sugar is 290. HELP!