Study indicates LDL levels may independently predict type 2 diabetes in women

MedWire (8/29, Goodman) reported that 'anti-oxidized low-density lipoprotein (LDL) levels are independent predictors of the development of type 2 diabetes in women," according to a study published in the European Journal of Clinical Investigation. Francisco Tinahones, of Virgen de la Victoria Clinical Hospital in Spain, and colleagues, recruited “465 women randomly selected from the municipal census in a town in southern Spain. Participants were aged 18-65 years, and were free of serious mental and physical illness.” After following the subjects for over six years, the researchers found that “women with no carbohydrate metabolism disorder at baseline had a 1.5-fold relative risk of developing one at follow-up if they had baseline levels of anti-oxidized LDL below the 50th percentile.” Notably, “women who had impaired fasting glucose or impaired glucose tolerance and levels of antibodies below the 50th percentile at baseline had almost a 10-fold higher risk of developing type 2 diabetes than women who had antibody levels above the 50th percentile at baseline.”