What insulin causes most weight gain?


Does anyone know which insulin causes more/easier weight gain? Would it be the long acting aka Lantis, and NPH/ intermediate acting, or something like nova log the fast acting?


Insulin has never made me gain weight and I have taken all of those.


Tina - Welcome to the forum.

I think you will find that Long Acting (Basal) insulin will cause you more weight gain. It is not the insulin, that is actually causing the gain but before taking insulin you were most likely not processing food properly and once you start on insulin your Blood Glucose starts coming under control and your body processes the food you eat better causing you to gain weight. This can all be managed for your particular case.


The key is finding the combination of insulin and timing of injection, that matches your eating, activity and sleeping schedule. Also may be impacted by other T2 meds you take.

Sometimes even more challenging with T2 based on how insulin resistant you are, and when.

Have you discussed this with your doctor?


I don’t think basal would cause weight gain, It would be the carbs and bolus.
If you find you are putting on weight, cut the carbs and that will reduce the bolus insulin. Insulin is a fat storing hormone.


Tina - as has already been mentioned it is not really the insulin per say but how your body is now processing the glucose. However there tends to be more snacking by some to prevent lows which adds to weight gain. Its also worth mentioning most “insulins” are analogs and not human insulin. The molecules are different and may react a little different person to person.

Whats more important is as a “T2” your pancreas is still producing some amount of insulin. Its when you eat you should be taking a rapid acting insulin to reduce the post meal spike asap. This will allow you to get back into a fasting BG range, reduce the heavy load on the pancreas and then your pancreas may be able to handle the fasting insulin requirements.

The best insulin for T2 meal time use is afrezza which is actually human insulin. It mimics pancreatic meal time insulin release. Because of its profile, the liver also gets back in sync turning off and on sugar release and as a result the chance of a hypo is very small especially when not taking other meds like metformin. Its available for $4 a day without insurance. http://www.insulinsavings.com

However, before even starting on any insulin or an antiglycemic for that matter you really should know what you 24/7 blood profile is and how certain foods impact your BG. For less than $200 you can get an Abbott Libre starter kit from Walmart. Most T2s after 3 month have a really good understanding of food BG impacts while using afrezza and really don’t need it longer than that. Two sensor which last almost a month run about $80.

Here is an article I saw yesterday on CGM use and BG profiling.
https://www.cnbc.com/2019/01/31/blood-sugar-tracking-useful-for-more-than-diabetes-commentary.html - Its where things are going with the ADA Standard of Care but why wait? The tools are here today and for $4 a day and $40 a CGM sensor there is no reason to wait. It may take them 5 years to update the standard of care.