This is kind-of belated, but oh well.
The year following my 22 birthday included:
Got married (just celebrated 24 years)
Graduated from College
Got first career job (kept it for 22 years)
Moved to a different city (lived there 10 years)
Won the lotto for $10M
Rented first house (bought 1st house 2 yrs later)
OK, the lotto part was only in a dream, but the rest all happened and made 22 seem like a fairly significant year in my life.