I can relate to that. Most of the suggestions people make are things I react to. Some are fine at first, but often I end up reacting after a couple of years. Or, with the Libre, I still react to it even though multiple barrier layers of tapes/sprays.
I have almost given up the pump and CGM both at various times because of this. I am really hoping that this hydrocolloid barrier solution works for me for a while. I have a major problem with reactions to infusion sets, too, so I’m going to try the hydrocolloid barrier with them. But they are a little more tricky, because I react to the canula/needle in addition to the tape. I end up with sites from the past several weeks all itching at once, tons of site occlusion alarms, and so on. I recently took a week-long pump vacation because of it. I do find taking an antihistamine every day helps, but I think you may do that already.
I have atopic dermatitis and I’m sure the reactions I’m getting are allergic contact dermatitis. I think having atopic dermatitis makes the skin way more sensitive than usual (I also have issues with lots of soaps, creams, deodorants, shampoos, discovered during this pandemic I react to Purell, even if they’re all unscented). I also react to the heart monitors. I had a fifteen-minute exercise test done and even that caused a reaction that was red and itchy for days. I think a lot of these adhesives, gels, and creams have shared ingredients. I am hoping to find out exactly which ingredient(s) I’m allergic to when I do patch testing with my allergist.
I think when you react to so much, it’s all a long process of trial and error to find out what your skin tolerates. And then more trial and error when you become allergic to something you tolerated for a while. It’s all very time-consuming and irritating (literally) and frustrating. I hope the steroid and Benadryl strategy work for you. I may give something like that a try for my next infusion set.