For those that might be interested! Scientists have identified nine genes that play a key role in increasing the risk of developing type 1 diabetes.
" From associations of T1D with aggregated trans-scores, nine putative core genes were identified, of which three—STAT1, CTLA4 and FOXP3—are genes in which variants cause monogenic forms of autoimmune diabetes. Seven of these genes affect the activity of regulatory T cells, and two are involved in immune responses to microbial lipids. Four T1D-associated genomic regions could be identified as master regulators via trans-effects on gene expression. These results support the sparse effector hypothesis and reshape our understanding of the genetic architecture of T1D."