Hypothyroid

My TSH was 4.96, and TPO-antibodies were super high.

I have a lot of symptoms, the big ones being: weight gain despite eating a lot less, depression / apathy, fatigue and inability to concentrate.

The MD only started me on 25mcg levothyroxine. I have a few questions:

1) Is that a really low dosage? Will it likely go up over time? I have another blood test in 6 weeks. I heard that supplementing with a really low amount of T4 might make the TSH go down, but can cause the T4 levels to drop even lower when your body realises it's getting the hormone from an outside source. Is that true? Am I just going to feel worse?

2) When might I start to feel better? The doctor said it will take weeks for the meds to have an effect, but I've read online that it might be shorter.

3) The MD said I could take the meds whenever during the day, with or without food, but I've read online that it's a bad idea to take them around the time of eating soy products, and I often have soy milk on cereal for breakfast. Should I take them in the evening instead?

4) Will the levothyroxine affect my BGs? It hasn't so far, but I've only been taking it for 3 days.

Thanks for any help. I feel so "off"; I can't wait for something to work!

That’s a low dose. Endos start peope on low doses & test frequently because too much is dangerous.

It all depends on if you need T4. Hope your doctor did tests to measure both T3 &T4.

Everyone is unique in their reaction & biochemistry & it can weeks to feel a difference. It also takes time to find the correct dosage.

Soy products are antagonist to the thyroid. I avoid soy.

Many people find they need more insulin when on thyroid supplementation.

Hi Emma: I was diagnosed with Hashimoto’s (autoimmune hypothyroidism) right around the time that I was diagnosed with Type 1 diabetes. Many of your questions I can’t answer, hopefully someone else will fill in the gaps, but I’ll do my best with a few questions (and these are just my personal experiences). 25 mcg is low, but when you are first diagnosed that is a typical dose (that’s what I got). Based on blood tests, your doc will make changes. It took me 10 years for the full autoimmune attack to complete, and I am now at 125 mcg. I was always told to take the meds first thing upon waking, well before breakfast. For me, it did take some time for my only symptom (extreme extreme cold, especially hands and feet) to resolve. But I was also recovering from the DKA that occurred at my T1 diagnosis, so that was a much bigger deal recovery for my poor body. But the symptoms did resolve, and I basically feel good all the time and have no issues with the thyroid. The synthroid did not have a big impact on my BGs, but did make my total daily dose go down slightly. It was not dramatic. Hope this helps, and I hope you feel better soon.

Well, for starters, we need to have an understanding of what the Thyroid gland is… and the Thyroid gland is a gland that controls our body’s metabolic functions. It does so, by taking iodine from the foods that we consume, and producing T3 and T4 hormone, which are absorbed by the body’s cells. How much hormone the Thyroid produces is a delicate balance, and it is dictated by the Pituitary gland. As the body needs more T3 and T4 hormones, the Pituitary will produce higher levels of a hormone called Thyroid Stimulating Hormone, or TSH, which signals to the Thyroid gland that it needs to make more of these hormones. Inversely, as the body needs less, the TSH levels will go lower. The TSH in itself, is merely a level indicator of your thyroid hormones, and of your Pituitary function. It holds no other function than that.

When your T4 levels are supplemented from outside, the TSH level will go down because the Pituitary gland will notice that, and it won’t need to “scream” so to speak, at the Thyroid gland anymore, to make more T4… It will NOT drop the levels of T4.

What can happen, sometimes, is that some Doctors only test for T4, and do not test for T3… so sometimes, folks still have symptoms after being on a medication for a while. 25 mcg of Syntrhoid are only a starter medication, and honestly, it takes a little while for the meds to have an effect on our system and for us to feel better. This can be anywhere from 6 weeks, to 6 months. You will likely not be upped by much, in my opinion, as your TSH was really not that high at all. For comparison’s sakes, I was diagnosed at 150.0 TSH level. I have to take 125 mcg daily. Synthroid is a medication that will only supplement T4. If your T3 is also impaired (which, you see an endocrinologist for this, and not a GP), you will need to take a medication which has both T3 and T4, like Armour Thyroid. Another thing to keep in mind is that if you have any antibodies present, those can throw off the results of a TSH… and a good Endocrinologist will need to go by your overall symptoms, your Free T3, Reverse T3, Free T4, and entire metabolic profile levels, to adjust your medication more appropriately.

As to your other questions, your doctor is absolutely WRONG. Thyroid medications need to be taken on an empty stomach, and preferably 30 minutes before eating, as many foods we eat which contain calcium, iron, fiber, and large amounts of iodine, can interfere with the body’s ability to absorb the replacement hormone. Such foods as kelp which are extremely high in iodine, should be avoided, and foods like unfermented soy products, because they are goitrogens – they can enlarge the thyroid, impair hormone absorption, and worsen Hypothyroidism. Limit yourself to fermented soy products, like miso, and tempe, etc. Tofu, and soy milk are NOT okay.

In some cases, Levothyroxine has been known to interfere with blood sugars. Some people will need twice as much basal as before, and some people have reported having low blood sugars, in contrast. Every person is different with their response, and you will need to be extra watchful with your blood sugars as you are taking this medication.

I invite you to join the group, Hypothyroid Diabetics, so you can ask questions of people in your same position, learn more about the Thyroid, and have people to relate to as you go on this new journey. :slight_smile:

Thanks everyone for the replies.

I guess I’ll give the soy milk a break, then. (; I’ll also ask about having T3 tested next time I’m in. As a comparison, my free T4 used to be 18.something (ref. range 10-22) - I felt great at that time! It’s now only 11, so right at the bottom of the range. Even if it’s “in range”, I think it must be too low for ME, because I feel like crap (either that or my T3 is low; it’s never been tested so I wouldn’t know).

My BGs have been lower than normal lately, so I expect if they do anything with the treatment they will get higher. I’m wearing a CGMS so I’ll definitely be on top of any changes.

I joined the group as well. (:

Unsweetened almond milk is very good & lower carb than soy milk or rice milk.

Thanks (: I do like rice and oat milk, but yeah, they weren’t great on the BG, so almond sounds like a good idea.

becareful with soya. Mary Shalmon has a book about thyroid dietetics ad she claims that soya in most forms ca interupt thyroid function

There’s also hemp milk. I haven’t tried that & don’t know the carbs.

i was dx’d with graves and thyrotoxicosis 18 years ago…i underwent radio-active iodine treatment…its been a battle since then.

25mcg is crazy low to fix such hypo symptoms. and for a doc not to test t3/t4 is negligent.

your body needs t3…and you can get it in supplement form. cytomel…or natural thyroid hormone, armour.

(((hug))) hypo is hard.

im going to suggest you take a multi-vitamin, b-complex, b12 supplement, and about 5000 mcg of vitamin d daily. this will support you until your meds are up to par. the b’s should be sub-lingual, but anything is better than nothing.

You had some pretty good answers but I also want to throw some stuff out here. Like Lizmari said, a good doctor will also test other levels. Your T3 is what effects your metabolism and also your weight. The Free T3 should be in the upper 2/3rds of the lab ranges to be considered optimal.

Besides waiting to eat after taking your thyroid meds, there are also some other things that can impact the thyroid meds. If you take cholesterol meds, anything with calcium in or iron, those can all lessen the effect of the thyroid meds. You should take those about 4 hours apart from any thyroid meds.

With Hashimoto’s, your TSH can really fluctuate so your doctor should not be going by TSH at all.

You said your TPO was high but didn’t say what it was. Mine was over 3,000 in Nov and was still over 1,000 last week. It will eventually come down on its own, but taking selenium can help that.

Like the others said, the meds causing BS problems is more of a YMMV type thing. However, Hashimotos can also cause BS problems, as can any inflammatory disease. I have been having problems with that and also know someone else going thru the same thing right now. I will have a couple weeks that I feel like I am injecting water instead of insulin and practically have to triple the amount of insulin I am taking. Then everything comes crashing back down and I go back to normal for a few weeks and it starts all over again.

I was looking for answers like you and found good information in a book called “The Thyroid Sourcebook” by M. Sarah Rosenthal. The author had thyroid cancer and a lot of thyroid conditions run in her family, so it’s written in a way that keeps people like us in mind.

I’ve been told to take my pill on an empty stomach at the same time every day by both doc and pharmacist. The book recommends the same. I am T1 and I haven’t noticed it having an impact on my bgs.

My original TSH was 8.3 and I felt better after taking .075 mg after about two months. The meds have to build up in your system, that’s why you have to wait to take the next blood test. Yes, it will go up over the course of your life, but once they find the right dose for you it will not need to be adjusted frequently. I was very sick during the time by thyroid was whack – couldn’t heal from infections, heavy periods, kept getting head colds for about four months until it finally got under control. Can’t blame the D for that because my numbers were always good.

It’s very frustrating and upsetting and I feel your pain, sister! Hang in, it will get better.