Has anyone heard of Maternally Inherited Diabetes and Deafness? I was doing research for a paper on MODY a few days ago and I came across this bizarre (and bizarrely rare) form of diabetes.
Has anyone else ever heard of it?
Have you been tested for MODY?
The reason I ask is that, with MIDD, there's about an 85% chance your mother would've had it. (It's something you can only get from your mother, but if you have the gene, you have about an 85% chance of showing symptoms.) Also, MIDD may not even come up as diabetes--as a mitochondrial disease, it could also just manifest with hearing loss or muscle weakness or any other number of weird things.
On the other hand, certain types of MODY have about a 50% chance of showing symptoms if you have the gene--some more, some less. I don't think any are as high as with MIDD, though.
The thing with me is that I do have muscular problems, though I (thank GOD) don't have hearing loss. (Music is extremely important to me--I don't know if I could handle it if I were to lose my hearing.) I definitely don't have MIDD, though, because it's my father who has diabetes--my mother didn't even get high BG from IV steroids during chemotherapy. (Proof that obesity is, at least in some cases, not a direct cause of diabetes.)
As I'm doing this research paper, I remember how well my father and I fit the diagnostic criteria for MODY. My endo keeps calling it "highly genetic insulin resistance". The thing is, the average hsCRP (high-specificity C-Reactive Protein) of people with T2 is about 2, for normal people .48, for MODY3 (the type we'd probably have), .2; mine's .3. It's definitely very low for T2 and I show no signs of IR (except a couple of C-peptides between 4 and 10, which could be accounted for by my being a little overweight). Most of the papers I'm reading have proved that for people who fit the diagnostic criteria for MODY (which basically excludes being positive for antibodies, being obese, acanthosis nigricans, high BP, and high cholesterol, and includes 2 or more generations having diabetes), something around 75% of the people have MODY. It's a scary number, and my family satisfies all of those...