i know for certain Disney World caused my diabetes.
i know for certain Disney World caused my diabetes.
Tell the truth Rick, wasn’t it the bottomless drink cup you bought while at Disney World.
Oh my goodness Gary, My dad asked me about mid morning of the first day if i was writing a travel blog of where to pee and buy drinks at Disney World.
I still think Frontier Land had the best Men’s room at Disney and that young lady at the Tomorrow land quick counter was a real looker. I mean when i was not throwing up into the trash can.
As you might expect that can really throw off the mood.
The researchers I mentioned in my earlier comment were looking for serious viral infections 1-2 years before diagnosis.
From what I understand, you have a gene or possibly genes that make you susceptible to getting type 1. Then they think a virus or viruses can set it off. Also a possible connection to getting diabetes if you had have covid, that’s a little more muddy.
But I don’t think they know the whole story. Does it count if you have the virus 6 months before because it takes time??? Since viruses never leave the body, can you had had the virus just once in the past? They just don’t know yet.
The first year I woke up to a 115 in the morning, (I had a meter I would test off and on because of an uncle that had type 1) that year I had a cold at the beginning of the year, a few months later a dog had died, and then a few months later my mom died…I have always thought stress helped set it off, but I also had a cold at the beginning of the year.
I believe it is largely, but not only or mainly, due to a Vitamin D deficiency.
The incidence of type 1 diabetes (T1D) has been doubling every 20 years. In Finland, the recommendation for daily vitamin D supplementation was gradually reduced from 4000-5000 IU in 1964 to 400 IU in 1992. Concomitantly, T1D increased by 350% in those aged 1-4 years, 100% in those aged 5-9 years, and 50% in those aged 10-14 years . However, since 2006, T1D has plateaued and decreased after an increase in serum 25-hydroxyvitamin D (25[OH]D) after the authorities’ decision to fortify all dietary milk products with cholecalciferol . Moreover, the worldwide association of ultraviolet (UV)-B light and vitamin D status with T1D and multiple sclerosis is now more than evident.
Source: The Big Vitamin D Mistake
I had a reactivation of ebv at the time of type 1 which happened in late spring. There were other factors I am sure, and I had obvious d symptoms for a long time before dka which should have been diagnosed. My whole body was inflamed in the two years before- I developed severe dry eye, and more, terrible reactions to foods, nightshades and more. I believed grains and gluten and chronic ibs played a role as well.
It is well known that viruses can play a role in type 1 and other autoimmune diseases. EBV is linked to multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes & celiac as well as several cancers, mostly lymphomas. It is thought the virus turns on risk genes for various autoimmune diseases. A few months before my dka I was sick and went to doc, they tested me for lupus and a bunch of other stuff but not D.
I think most people have some hereditary autoimmune diseases in the family as well. Other members in mine had asthma, hashis, ra and graves.
Diagnosed on November 29th 1991 JUST after recovering from the Flu in DKA, coma the whole nine yards. I think those of us who get type 1 after getting a virus are predisposed to autoimmune disorders but you have to get one of the bugs first to set off your immune system. There are many ways to set your immune system off but illness, stress, severe allergies, etc. can all do it.
This might be old knowledge, but, from what I’ve read, T1 generally takes 2-3 years to develop, some less, some more, and does not become evident until about 75% of beta cell function is lost, making the idea that flu triggers T1 seems implausible at least as an immediate cause. As an idea, the flu relationship could be the other way around, in that a weakened immune state of impending T1 you are more likely to get the flu, or succumb to other mental or physical problems, or the the flu can be the proverbial ‘last straw’, not causing, but accelerating beta-cell decline.
The most recent autoimmune trigger I have read about is enterovirius, and I have long read about milk proteins - before my diagnosis, I was drinking up to a gallon a day - or even lowered helicobacter pylori infection rates - fighting it off could protect us against the autoantibody response - as well as a microbiome relationship.
A ‘soft’ article, a seemingly comprehensive discussion of causation:
Enterovirus and the gut:
Debates the validity of virus as causation:
100% agree with JamesIgoe!
Imagine this: your immune system has been killing off your beta cells for the past years but you’ve been barely getting along with the reduced insulin production.
Then all of a sudden you get the flu and you now need twice as much insulin. And your pancreas cannot keep up at all. Whatever beta cells are left are pushed to their limit and beyond. Shortly afterwards (weeks) you in DKA and the doc in the ER puts you on insulin.
My theory is not that the flu caused an immune reaction that killed your beta cells and caused diabetes. My theory is that your body had been killing off beta cells for the past year, it’s just the flu brought it to the surface where it was easily diagnosed as DKA following the flu.
Worked for me. Nasty viral cold in late October, dx’d in mid-December. No suspicion of T1 whatsoever before that.
Of course sequence doesn’t prove causation, but anecdotally it fits the pattern.
ETA: @JamesIgoe’s scenario of immune-impaired pancreas first for a year or so, then accelerated by an anti-viral immune response seems plausible. I’ve certainly read a lot of people describing a slow-onset experience, especially adults, where they were logy, losing energy and weight, over a long period, approaching a year or more. That definitely doesn’t describe my experience, though. I was definitely not aware of any symptoms until after my cold that fall, and then they went from Geez, why do I feel like I have a hangover all the time to the whole peeing/thirst/nausea/screwed up eyesight stuff over just a few weeks,
I was sick for about 2 weeks. But, I was 11, so I don’t remember precisely. 2 weeks was WAY too long to get me to the hospital. I just barley pulled through. I’m pretty sure I was still in school throughout. But, I was severely ill. The teachers were calling my parents to tell them so. My parents were not very smart parents. They were good with plants. They probably should have just stuck to plants. Somehow, I lost 20 lbs and they didn’t seem to notice. So, I take their account with a grain of salt. But, they say I had the flu.
My diseases progression mirrors the one I described, with gradual beta cell loss over time, but it was long ago when I was 17 - I’m 60 - and the only trigger that I’ve read is I could consider, other than the standard autoantibody one, is stress.
I entered a detox unit for a short-term mental health issue for two weeks, although not drug-related. My health was fine, but after getting out, a short time later, I asked to go back in - nothing scary, just didn’t feel right. They redid my urine and they found sugar, and that hadn’t been there before, with a GTT to confirm.
From what I remember, my BS was never insanely high, at first high-hundreds, then later in the 200’s, but the doctor, by specialty a neurosurgeon, gave me drugs for Type 2’s, even though on appearance, at 6’4" and 170 lbs, one would assume a Type 1, and if he did treat me correctly I believe he might have preserved my pancreas, at least a bit. I went off to college, and the endocrinologist I was given, somewhat accusatorially, told me I had to go on insulin, if not in 6 months then in 2 years. I wasn’t fighting him, but I did not take care of myself back then.
Anyway, after about 18 months i had lost 35 lbs and was sitting on bones. I looked like I was in Auschwitz, no disrespect for the people that truly suffered, just skin and bones. I was hospitalized and put on insulin. After that, well, you know how it goes…
It’s hard to know what triggered it. You might think it’s flu but is it really?
I had a very fast thinking doctor who swabbed my nose when I was in the ER. And I still had the virus.
I had coxsakie b virus.
It is well known to trigger the immune response for type 1.
I read an article about covid sparking the same thing in other people recently.
Really any virus could do it. It’s our overactive immune systems that go haywire and kill off our beta cells.
No viral infection in my case, and no other extended family members with T1D.
Was diagnosed in February, in kindergarten. Mom noticed weight loss, despite being hungry all the time and drinking lots of water, no prior viral trigger.
One speculation was that T1D was related to my mom having to stop breast feeding due to infection, a theory that has been disputed as possible tie to T1D.
As I faintly recall from 49 years ago, I think that I had strep throat (which I think is bacterial rather than viral). Shortly after that … like 3-4 days … I began the peeing drinking cycle. Although I lost 14 lbs over the next 10 days, it was not until my vision got blurry, that I got myself into the student health center. That was as a 22 year old first-year grad student.
Am I sure it was bacterial? No! But certainly, in my mind, being sick was clearly the trigger.
I think the problem here is that people are associating an immediate event with Type 1 diabetes. It doesn’t work that way. Regardless of the trigger, the effects typically are not seen for 2 to 3 years later. Granted, there might be instances when an illness can cause rapid beta cell loss - I don’t know of any, but … - the one-to-one relationship that people see is either an effect of having Type 1, or unrelated, but that flu-like illness brings people in front of doctors and then it gets diagnosed.
I believe that I was a healthy kid until I started showing all the signs of diabetes in the late summer in 1959 when I was 8. Even though my mom took me to the pediatrician twice because I lost 20 lbs and had all the constant peeing and thirst, no one checked my blood, until I was nearly comatose and hospitalized. They kept me 3 days and released me with almost no training.
No previous illness that I know of.
I’ve heard the breast feeding theory before.
And out of 4 kids in my family, I was the only one who didn’t breast feed because my mother was sick and by the time she recovered I was happy with a bottle.
That’s not a scientific relationship really but it’s food for thought. Most of a child’s immunity comes from breast milk when babies are under 3 months.
Then they slowly add their own as they are exposed.
And in the old days…
There weren’t prepared infant formula. Not sure what I was drinking from bottle, maybe.evaporated milk ? (1960)
“If you were not breastfed as an infant, you were fed a formula created by mixing 13 oz of evaporated milk with 19 oz of water and two tablespoons of either corn syrup or table sugar. Every day, parents prepared a day’s worth of this formula, transferred it to bottles that they had sterilized in a pan of boiling water, and stored it in a refrigerator until used. In addition to formula, infants received supplemental vitamins and iron.”
At one point, my mom read article regarding diabetes more common in children not breast fed. Asked her doctor, and told it did not likely cause it.
But none of my many siblings has diabetes, and all were breast fed.