Thank you. Yes the data on insulin sensitvity issues do seem cummulative and I have no argument. Metformin has many effects.
Lab data and research data I see on metformin and on effigy work suggests data of aprox 2.5 hours from digestion to max dose level in blood. That dose lasts from minimum 1 hour to 3 hours. For me 2 hours. It exhausts in about 1/2 to 1 hour from that peak dose.
John Hopkins Childrens report did say the affect worked on some folks and others are not genetically pre-disposed.
Clearly, nobody should try this out without medical assistance , approval, guidance and a cgms for safety.
In my case, at no time did we read scientific journals and try this out. It was arrived by accident when 5 yeras ago I took my dinner met dose late at 12:00 midnight. BG in am was 187 instead of 238. Repeated this and found same result.
Next Doctor put another dose at 10:00 pm and the morning BG was 120 to 140 and repeatable.
Next scouted out all the research on metformin and shocked by what was found.
While the arguments are vehement about how met presently works; all data sheets and scientific articles admit they do not know how met really works and advance theories.
Even more bizarre is that met gets exhausted unmodified with no digestive products which really asks what is met really doing - Sinalling and or catalyst?
Best wishes and good luck.