I haven’t critiqued this, so someone will likely ‘kick the tires’ with concerns about the study design, patient matching, and exclusions, but it looks legitimate.
Meaning This study suggests that BMS was associated with greater reduced mortality compared with GLP-1RAs among individuals with a diabetes duration of 10 years or less, mediated via greater weight loss.
Conclusions and Relevance In this cohort study, BMS was associated with greater reduced mortality compared with first-generation GLP-1RAs among individuals with a diabetes duration of 10 years or less, mediated via greater weight loss. No differences in the risk for mortality were observed between the treatment modalities among individuals with a longer duration of diabetes, nor in the occurrence of nonfatal MACEs among all patients.