I understand that there’s a relationship between the start of Byetta and pancreatitis too. I (with a history of pancreatitis 3X related to gallstones & ERCP) was prescribed Metformin after stopping a short trial of Januvia with no adverse side effects. I learned of the Januvia cancer & pancreatitis connection months ago from this website. (Noteably, Byetta’s origin is in the saliva of the Gila Monster and there’s documented pancreatitis associated with that animal’s bite. Plus, lactoc acidosis (and pancreatitis) is a rare serious side effect associated with Metformin, hypos are associated with insulin and sulfonylureas, and heart failure and edema with TZDs.) Ooooppss…I’m rambling.
Regarding Januvia you wrote “There’s no data reporting the number of acute pancreatitis cases before the drug was approved.” The FDA didn’t seem to find a relationship between Byetta and pancreatitis; I understand that Byetta got through the FDA w/o a panel review.