Symlin is a very tricky but very beneficial treatment - you will get very frustrated, because everything you currently expect from how your insulin will work and what your carb-to-insulin ratios will change. I gave up several times, but I made a commitment to get used to it and it has HUGE advantages once I got ‘stabilized’ - which to me means PREDICTABILITY.
Here is a short list of advantages - Symlin will make your insulin MUCH more effective - you will, when fully dosing, use MUCH less insulin to control your blood levels - and since insulin is the main cause of weight gain in ALL diabetics, you will begin to loose weight without much effort. Also, at least for me, I finally now truly feel full after a meal - I had not felt that way in the last 35 (+/- years since I was diagnosed as a Type-1. I actually do not now finish EVERYTHING on my plate now, so I have had to modify my habit from bolusing BEFORE eating to bolusing AFTER I eat to be able to only bolus what I actually ate - not what was presented to me to eat (I hope this makes sense - it is important).
Although it is a LOT of work, and often times confusing and dangerous (for me, many more hypoglycemic episodes as I tried to learn and predict how ‘well’ it would work - it is different with different foods) to keep in mind the compelling reason I subjected myself to this process on a ‘theoretical’ basis - - - the pancreas secretes MORE hormones than just INSULIN - in a healthy pancreas, a SYMLIN-like hormone is also released and helps ‘balance’ a healthy person’s BG level naturally - the more we can more closely emulate a healthy person’s hormonal balance, the healthy we will be… that is what I believe.
My final insight - and many will not want to consider this as an option because it is “OFF-LABEL”, but I have started mixing Symlin with my insulin and pumping both through my pump. It is also a little tricky, but has many advantages - - - I do not have to give my self shots at meals, I more closely emulate how a healthy pancreas works, and my overall insulin efficiency has lowered my overall daily insulin use substantially - - so I am loosing weight with little effort. I was not ‘overweight’ but I was 15 - 20 pounds over my ‘ideal’ target. This method has returned me to my thinner, more active and younger feeling self and I highly recommend it to those willing to experiment with the process. (FYI - I mix 1 part Symlin with 10 parts Humalog as my ratios, but I have heard of widely different mixtures - this is something that again proves that EACH of us has to find what works for us on a personalized basis, not doctor will be able to tell what to do, they have no idea how any mixture will effect us a an individual basis).
Hope I did not scare you away from Symlin, but if you are committed, it will improve your life - I promise.