The Nature Magazine published an article called 'Genetic and epigenetic fine mapping of causal autoimmune disease variants'. In this research they have tried to identify nucleotide changes in the DNA and the autoimmune disease they potentially cause. Not surprisingly they identified clusters of diseases that might have something in common or are even co-conditions. To some degree these findings can explain why some conditions are more likely in association with Type 1 diabetes.
I took their general association map and reduced it to those candidates that might have some association with Type 1:
The more intense (red) the color the more active is the specific gene change for this disease (as far as I have understood the terms enrichment and SNP).
To some degree there seems to be an association of Type 1 with these autoimmune diseases:
1. Crohn's disease
2. Multiple sclerosis
3. Celiac disease
4. Systemic lupus erythematosus
5. Ulcerative colitis
6. Primary biliary cirrhosis
7. Allergy (who would have thought? ;-)
8. Rheumathoid arthritis
9. Juvenile idiopathic arthritis
I am missing conditions like Hashimoto and other thyroid related conditions with strong association to Type 1. I would also suspect that skin conditions like Lichen sclerosus and Lichen planus are associated.
What associations do you see in this map or the more general mapping?