Pregnancy and autoimmune diseases

Hi guys,
I am looking for information and stats on pregnancy while having type 1 diabetes and hypothyroidism. What is the chances that my kid would someday also have these diseases, what are the risks for me and the baby, what is the best age to get pregnant? I can find info on these seperate but not combined and I don’t want to make a doctor’s appointment just for my curiosity.

I think the chances of inheriting diabetes from the mothers side is something like 10% and if your hypothyroidism is autoimmune then probably the same chances. If your diabetes is very well controlled (nearly non-diabetic) then the risk to you is basically the same as for a non-diabetic. You would however be referred to a high risk OBGYN that specializes in diabetic pregnancies. While many women have babies later in life nowadays technically anyone over 28 years old is considered higher risk.

CGM’s can make pregnancy much safer for diabetics and like I mentioned above strict control of BG’s is crucial to a healthy pregnancy and baby. If you are planning to go ahead with trying to get pregnant it is much better to see a Dr. before starting than being surprised and not knowing everything ahead of time.

HERE you can find a TON of great information:

https://beyondtype1.org/pregnancy/

It is difficult to estimate the risk of the full variety of potential autoimmune diseases which may be inherited along with the diabetes risk, in part because many of these conditions are quite rare. The one I developed, for example, Wegener’s Vasculitis, has a prevalence of about 1 in 100,000, so the small numbers make it difficult to establish a reliable association with diabetes. Other more common autoimmune conditions linked to diabetes such as Multiple Sclerosis have better data.

Of course the main risk is for transmitting type 1 diabetes, which has a prevalence of about 1 in 300, or 0.3%, in the United States among those 18 and under (D. M. Maahs, “Epidemiology of Type 1 Diabetes,” Endocrinology and Metabolic Clinics of North America, 39 (3) 481-497 (2010)). The risk of type 1 diabetes in the children of fathers or mothers having type 1 diabetes is described in the following study:

"Diabetes 2006 May;55(5):1517-24.

Differential transmission of type 1 diabetes from diabetic fathers and mothers to their offspring.

Harjutsalo BA, et al.

We studied the incidence of type 1 diabetes in the offspring of patients with childhood- and adolescent-onset type 1 diabetes and several risk factors predicting the risk. We defined the diabetes status in the offspring of all probands who were included in the nationwide register of Finnish type 1 diabetic patients diagnosed at the age of < or =17 years from 1965 to 1979. A total of 5,291 offspring at risk contributed 72,220 person-years of follow-up between 1970 and 2003. Of them, 259 offspring developed type 1 diabetes by the end of 2003, giving a cumulative incidence of 6.7% (95% CI 5.9-7.5) by the age of 20 years. The incidence of type 1 diabetes in the offspring between the years 1980 and 2003 was 35.3, 44.6, and 44.6 per 10,000 person-years for the age-groups 0-4, 5-9, and 10-14 years, respectively. Poisson regression analyses showed a marked increase in incidence of 5.3% per year from 1983 to 2003. The greatest increase occurred in the youngest offspring, aged 0-4 years. Of the offspring of male probands, 7.8% were affected by the age of 20 years compared with 5.3% of the offspring of female probands (relative risk 1.7 [95% CI 1.3-2.2]). The young age at onset of diabetes increased the risk of type 1 diabetes in the offspring of diabetic fathers but not in the offspring of diabetic mothers. In conclusion, our findings revealed that in the offspring of type 1 diabetic patients, the increase in the recurrence risk of type 1 diabetes was not more rapid compared with that in the background population. In the multivariate analyses, statistically significant predictors of type 1 diabetes in the offspring were male sex of the diabetic parent, young age at diagnosis in the male parent, and the more recent year of birth of the offspring."

So the risk of a type 1 diabetic father passing on the disease to his children is 26 times higher than normal and that of a diabetic mother is 18 times higher than normal.