I decided to start a new topic as I’m hoping to catch the eye of anyone who may have some knowledge or experience with triple therapy…
Specifically metformin (met) + sulfonylureas (su) + thiazolidinediones (TZD)
So let me just tell you this first off-I successfully stopped mixed insulin late August 2019… my edema on the lower legs disappeared after 4 days and I’ve felt a whole lot better since… I continue to use Glucophage XR (1 x 500mg morning and 2 x 500mg before bed) and have now added (after consultation with my GP) Glycomin (Glibenclamide from the sulphonlureas family (1 x 5mg morning and 2 x 5mg early evening) and there has been some, but not nearly enough, progress.
I’m very happy to report that my numbers are constantly low-teens now (I now consider a “high” at 15 mmol/L whereas prior to this I regularly had 18 mmol/L and higher after meals) but I’m very disappointed that, even with my change of eating habits (I now fast for a minimum of 15 hours per day) that I’m never lower than low-teens.
Essentially it does not matter how long I fast, (or not fast) I will always, always be higher than 10 mmol/L (I’ve been monitoring for 2 weeks now and it doesn’t matter if I test upon waking up, or upon fasting from 7pm the previous evening to 2pm current day it’s never less than 10 mmol/L).
Before I give up and go back to insulin’s I do want to consider tri-therapy and my option is to add a pioglitazone to the mix. What are your thoughts guys? Do you have experience with them? Just in case you were wondering I have appointment with GP soon to discuss and get his opinion too…
I’ve done some research and found that pioglitazone has been shown to reduce the risk of heart disease and the first-ever diabetes drug shown to reduce the risk of strokes(which is always good)but at the same time I’ve read that it has become less popular with patients due to side effects (including weight gain (which is the last thing I need), increased edema and bone fracture risk and some have been diagnosed with bladder cancer) but perhaps the pro’s outweigh the cons? Maybe this could be the one that tips my favour?
Whilst I’d love to be able to afford medications like Jardiance it just isn’t financially feasible so it’s a process of elimination I guess? Your thoughts?