In response to your post TraciS, I have been on Victoza for over 2 years and lost over 30 pounds. Prior to victoza, I was 1 point away from being diabetic Type 2. While my regular dr considered putting me on insulin, I ran to an endocrinologist who put me on Victoza and that helped me tremendously. We discovered that I had hypothyroidism and had other issues that no matter what I ate or how much I exercised my weight would not change and I would be extremely lethargic, depressed, could not sleep, and anxious. Now, bare in mind even when I was over weight I watched what I ate and jogged 3 to 5 miles a day with no real results. I thought I was going crazy! lol... Now, I still watch what I eat, I exercise regularly (12 to 15 miles a week) and with my synthoid and victoza I have never felt better. So, with that history and from what I have heard, getting off victoza and retaking it again would have the same effects. Lose and gain again.... I don't think that yo yo will not help in the long run. In my experience, what I do know is that the dosage level is what makes the difference. So, talk to your endo and maybe he can increase the dosage and with diet and exercise you can go back to your desired weight and healthy lifestyle. I hope that helps!!!