Amylin Analog

I came across discussion by Dr.Bernstein in his book about "amylin analog" medicine. I was wondering if anyone is using this medicine? How is your experience with this drug along with insulin intake. I use insulin pump. Does this medicine comes in oral drug form or we have to take it using syringe?

Reason that I'm curious is that I want to curb the appetite and slow down food emptying from the stomach after major meal.

Here are some links about this drug.


I think, but am not sure, that this is what Symlin is. I tried it several years ago and didn't like it much (it made me sick to the stomach after I took it, even after several weeks) and it would always, always make me go low. But I know some people love it and have a lot of success on it.


some T1 take metformin for appetite and delayed gut emptying. I would prioritise with a LCHF diet that I know several T1's are using for BG control and weight-loss, the same as a lot of T2's

it’s a long page and a few good video’s

For me, the more carbs we eat the more carbs we want. they don’t give up easy

you may find it's best to redo your basal testing if you lower your carbs

Symlin (Pramlintide) is essentially synthetic amylin. It's only available as a prescription and it's administered by injection.

Classified as an "incretin" hormone because it affects the production of other hormones, amylin acts on the central nervous system to

  • slow the emptying of the stomach's contents into the small intestine, where it is then absorbed into the bloodstream
  • blunt the secretion of glucagon by the pancreas (ironically, people with type 1 diabetes secrete extra glucagon right after meals), and
  • decrease appetite

By slowing digestion, reducing food intake, and minimizing glucagon production at mealtimes, amylin minimizes the blood glucose rise that occurs after meals.

- Gary Scheiner, Think Like A Pancreas (Boston: Da Capo Press, 2011), p. 50

Thanks everybody for participating in the discussion. As I use pump to get insulin, i dont want to get amylin analog in injection form. I read that it should not be mixed with insulin. So I was thinking if there any oral medication/ pill made of Amylin analog?

No, unfortunately. Symlin, like insulin, is a large protein molecule that would
be broken down by the acid and digestive enzymes in your stomach and intestines. That's why there is no oral insulin as yet.

I like the mechanism of these drugs, but I've always been pill shy. My Doc has wanted me on baby aspirin for years. Wont do it. I think I'm more comfortable with an injection. I sorta think that taking oral meds for long periods of time, sometimes ages one's liver. Being diabetic already, effectively, ages our organs. I'm protective of my liver. I treat it like some kinda organ primadonna. I'm short one pancreas already and don't want to come up short on another organ. I have always had high post-meal spikes. I think that met or Symlin could be good, but whats your guys's perspective on taking additional medications?