Jenny is right about the insulin potency being U-40, and you will need to adjust dosages accordingly (if you use a U-40 syringe there’s still conversion required – just remember that U-100 is 2.5 times as potent as U-40). Dose conversion is more of a mathematical calculation, but you may wish to error on the side of caution and use slightly less until you know how its response will be for yourself. As for Vetsulin (which is also sold under the brand name Caninsulin), keep in mind that is insulin zinc suspension, which is more commonly known as Lente insulin (which is itself made from a combination of Semilente and Ultralente) which is a medium-range insulin in terms of time-activity profile. It is/was indeed superior to NPH (at least if you believe the medical journals) for a host of reasons, but it will not replace a short-acting insulin for meal coverage. You can buy (without a prescription) porcine Regular insulin made by Wockhardt in the United Kingdom from a Canadian pharmacy online. One source for that is
My understanding is you still need a veterinarian to prescribe it, so its not exactly an over-the-counter medicine as the old Lilly Iletin II Porcine L(ente) insulin was.
As for safety, the product you’re asking about is manufactured by Schering-Plough (an American-based pharmaceutical company based in New Jersey) in the Netherlands. To be FDA-approved (which Schering-Plough’s Diosynth and Organon units both are), they must still pass all FDA-mandated requirements, and the manufacturing process does not differ in terms of purification for ALL insulin (both animal-sourced or biosynthetic) regardless of whether it is marketed for human or animal use. All insulin, whether it is biosynthetic or animal-sourced, goes through a a 14 stage high pressure liquid chromatography process (HPLC) which ensures its purity, which is exactly the same regardless of species of insulin.
As for the allergic responses, realize that porcine insulin differs from human by a single amino acid, and that is actually more similar to “human” insulin than Lantus is, which differs from human insulin by 3 amino acids, or Novolog and Apidra which differ from human insulin by 2 amino acids. As noted, the HPLC purification process ensures purity of 99%. Most reports of allergic reactions occurred prior to the late 1970’s when HPLC purification processes were developed. Many people had more problems with bovine insulin, although realize that the percentage of allergic reactions according to the clinical literature indicates about 5% with porcine, and 4% for human, which is not a statistically significant difference.
Good luck with your trial and keep us posted on your experience!