So I stepped on the scale today when I went to see my NP for some pump tuning and prescription modifications and was shocked. I had noticed my clothes getting looser and some other visible signs, but I did not expect such a dramatic drop since my last visit approximately one month ago. Four weeks after starting Symlin, I had lost about 12 pounds. I had my body fat checked at the gym this evening and the great majority of that weight loss (24.2 lbs) was fat. My NP and Endo both say this is normal and that I haven’t even plateaued yet with my weight loss!
Prior to taking Symlin, I was having a very hard time losing fat once I got to a certain size. My body simply would add muscle in response to exercise, increasing my weight but decreasing my body fat percentage.
I suspected a reduction in insulin would more than likely break this barrier but I prefer a balanced diet over one that is “zero carb”. I did not realize just how much of a difference it would make. My basal rates are the same as before, but my meal boluses clock in at approximately 30% of what I would need without Symlin.
That said, the effect on my appetite is also profound and cannot be discounted. I eat a lot less than before and get full very fast, sometimes to my disappointment because the food is so good. Symlin is a synthetic form of amylin, which islet cells produce along with insulin and glucagon. Without it, you have a much harder time feeling full when you otherwise normally would- and should. Amylin also tells your liver to stop dumping sugar into your blood when you eat and do not need it. And of course, the oft-mentioned effect on the stomach, slowing down digestion and eliminating the post-prandial spikes.
I didn’t realize it until I read the literature, but Symlin is the only other drug besides insulin approved to treat Type 1 diabetes specifically. Has anyone else tried Symlin and had a similar or different experience with it?