Does anyone else experience overnight highs with Tresiba? I’ve been on it for 5 months, woke up with a flat line every morning. All of a sudden 8 nights in a row, my numbers climb steadily and I’m woken by my CGM alarm around 2-3am to dose insulin for the high. Why would this be happening? I don’t eat after 7pm and I eat light. I inject around 10pm. I tried increasing units. I tried a new pen, I even tried a new pen from a different batch, still getting overnight highs. Any suggestions? Thank you.
I take Tresiba once a day around 6PM.
I find it has a “lull in activity” in the 6PM-10PM timeframe and then picks up strong again 2AM-6AM. This works out well for me because I need the “pick up strong” in the early morning hours again.
I think this kinda corresponds to your 10PM shot and 2AM lull.
If at the same time, the previous days Tresiba is strongly fading out, then I think this is the lull you and me are seeing.
Below is tresiba activity graph. In the perfect world the lull from 0-4 hours after injection would be filled by the remaining activity from the previous day’s shot. It might sometimes work this way but other times I think this overlap is less effective.
Wow great info thank you! Tonight I’ll begin taking my shot at 6pm and see how it goes. Would be nice to sleep through the night. Thank you thank you
I just started Tresiba 1week ago the first few nights were awesome then it started I was high till 4 then it started to work. I take my bedtime insulin at 10 moved it to 8 nothing the same. So last night I did it at 8:30 did some cardio to help speed it up epic fail low all night I’m so confused on what to do.
I was told Tresiba takes a few days to stabilize so make changes slowly and give it a few days before changing again. I recently had overnight highs. I changed my shot from 10pm to 8pm and it helped a little but still had overnight highs. I slowly increased my units 1 by 1. From 8 to now 11 units over the course of about 10 days. Last night finally I did not have a high and woke up with a 113. I’m not much help myself being no expert but wanted to explain my recent challenge and what worked for me. Good luck with things.
I take 50 units at bedtime that’s seems like a lot to me and should work but I’m not giving up on it
I take my 14 units of tresiba in the morning, around breakfast. I don’t really have highs or lows during the day, since I’m eating throughout the day and take novolog before meals when needed. I just make sure I have somewhat of a high card snack before I go to bed, so my BS doesn’t bottom out.
What’s interesting is the graph is taken at 0.4u/kg, an amount I’ve never been able to get close to without extreme hypos at night. I wonder if anyone has done research on the duration at different dosages.
I know, typical TDD’s are often in the 0.5u/kg ballpark, and basals (rule of thumb) are half that. A lot of tudiabetes members who are frequent posters have substantially smaller TDD’s than that (but I’m not sure we’re really “typical”).
I have been doing OK with once a day Tresiba dose that is in the 16-18 units ballpark. This is actually a reduction from my previous Lantus 20 units a day (split two ways because I never felt Lantus was very flat either). I take it in the evening and have a nice broad boost in its absorption around the dawn hours which works well to defeat dawn phenomena. It works really well for that. When I first switched to Tresiba it felt like the basal was running out of gas in the late afternoon but after several months it feels about right.