Trulicity no loss

I am disappointed that I have not lost any any weight on trulicity. I am type 2,plus hashimotos thyroid disease. I am also on Tresiba. I eat well,with little splurges as my CDE says. A1C is 6.3. I am 72. I am a good exerciser. But feel like I have failed. Trying to loose weight past 30 years . I feel like this is what my body is,look like my grandmother who was very obese. I am 30 pounds over weight. Any ideas. Nancy50


Hi there @Nancy50,
I am T1D for 54 yrs this month. Only thing that works for me regarding keeping my weight at a good level - which I’m sure you already know - is to keep high glycemic foods to a minimum. That means minimizing pasta, rice, french-fries, potatoes and all other high-glycemic foods like cake and things to minimal levels.
If you have not tried that maybe give it a try? I don’t want to respond like you’ve not tried this before.
I would also get your thyroid levels checked to see if your body is producing enough thyroid for your body. That is a very common problem especially for T1 and T2 diabetics.
Eat lots and lots of low carb veggies that do not need insulin tho process. They keep you full longer too! Spinach, red peppers (not spicy hot ones unless you like them!), lettuces etc.
Insulin stores fat too so if you moderate foods that require insulin for eating lots of these veggies should help you slim down for sure.
Wishing you lots and lots of ease reaching your goals here. And if you’ve already tried what I suggest, please forgive my suggestion!


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The only way I can keep my weight at a good level is by tracking calorie intake. It’s easier to do since I’ve been on semaglutides for the past 9 years, but even with the meds, if I don’t track my calories I can’t be trusted not to eat too much. It really comes down to calories in vs calories out.

I’ve been trying to lose weight for the last 15 to 20 years but as I got less & less exercise it got more & more difficult. The only success I had was during COVID when I was blocked from traveling so no airline snacks/food, hotel breakfasts & wining & dining clients. No weddings, no funerals, no birthdays, no holiday parties and no drinking & dining outside of the house.
I decided this would be a good time to go on a long term sustained calorie restricted diet with no sweets, no pasta, no bagels, no donuts, no pie, no pancakes (you get the picture).
I began eating 4 Oroweat keto bread roma tomato & mayo sandwiches every day for a little over 18 months. Each sandwich was 250 calories each so a max of 1000 calories a day with an occasional additional sandwich or two if I got significant exercise in that day. So a max of 1500 calories.
I started at 305 lbs at 6’2 and 61 years old.
I lost 20 pounds in the first month but then plateaued eating exactly the same thing and amount of calories and I didn’t see any real weight loss. After about another 4-6 weeks I began to see more weight loss of another 10 pounds but then hit another plateau for another 4-6 weeks before I dropped another 10 pounds.
After 6 months on this diet with excercise (walking at least 10K steps/day) I was as 265 pounds but at another plateau. The next 6 months I was down to 250 pounds & another plateau which seem to last longer so I started to do intermittent fasting 16/8 & 6 months later I was down to 235 which was actually a good weight for me.
This is where I went very wrong.
I decided to test my Intermittent fasting regime where I was still eating no more than 1500 calories each day and wondered if it really mattered how much I ate and what I ate in the 8 hour eating window.
I began to eat all the things I was missing like a pound of pasta, a quart or more of ice cream, a few NY bagels, etc in my 8 hour window and was shocked to find I had lost a pound by the next day, 10 pounds in a week and 20 pounds in 2 weeks! I was now down to 215 pounds and was thinking what a great diet to eat whatever you want in any volume as long as you don’t eat for 16 hours until you do it again.
Unfortunately my altered intermittent fasting routine was not the reason for the last, fast 20 pounds in weight loss in 2 weeks. Instead it was that I thrust myself into Type II diabetes because I also became very lethargic.
I went to the ER to get checked and my bloodsugar was as 575 and my A1C was 16.5!
They admitted me into the ER and confirmed my “eat whatever I want in 8 hours” put me on a path to the high likelyhood of diabetic coma which has symptoms like rapid weight loss and lethargy.
After all the treatments & medications to stabilize my blood sugar, A1C and other vitals my weight had climbed back up to 270 over the last year so I’ve started my 4 sandwich a day routine again but with some modifications/options so I can stay on it when I travel.
I will either eat my tomato/mayo on Oroweat keto bread or as an alternative I will have only 2 slices of keto bread/1 ounce of guacamole on each slice with everything bagel seasoning & a little sour cream at each meal.
So far I have lost about 10 pounds in the last 2 weeks and hope to get back down to 235 in the next 6 months.
I have found I can eat a bagel or piece of pound cake as long as it has been previously frozen and I have eating some protein immediately before such as 2 eggs, bacon, sausage, chicken, salmon or sardines. This reduces the BS spike by at least 50% so a splurge doesn’t kill you. I also never splurge unless my BS is below 100.
I hope this helps. Evidently your body needs time to retrain where your ideal weight should be. It takes many months to go down just as it may have taken years to slowly see your weight creep up. Getting old surely doesn’t help.
Good luck!

I see my endo in 2 weeks. I will have to have a good discussion. Thanks everyone!

Nancy Matulis

“Be the reason someone smiles today”

@Nancy50 ,

My parameters are pretty much identical to yours, except that I am male.

My endo believes that Ozempic is more effective than Trulicity for both weight loss and insulin reduction, and that the newer congeners which should soon be reaching the market will be more effective still.

Good luck,