I and my wife have type-1 diabetes since last 16 years. We married three years ago. Now we want to have a child. But in one of the articles from American diabetes association, They have mentioned chances of type one diabetes in the child. My anti-thyroid antibody test is positive. If we have a child, it will have 50% chances of type-1 diabetes as per the article. It is a very high probability.
Any of you does know about similar kind of study done by others? I want to cross-check before taking any decisions
I have heard from somebody that this study has been focused on North American people and the probability will differ for south Asian people. (We are from India). Does anybody know about probability in case of South Asian or Indian?
Do you know any parents who are diabetic and having diabetic or non-diabetic child?
We really want know the probability of type 1 diabetes of our child if we have.
Thanks for reading and we will be very much grateful who can provide any helpful information.
I don´t have any kids but my cousin is also type one, diagnosed at age 6 or 7. She has three children, none have diabetes.
The information in this article is news to me, I didn´t know that the risk could be so high!
I hope someone is able to help you with your questions!
Good luck.
Must be a whole bunch of people living in North America who aren’t North Americans… I was always taught that Native Americans are the indigenous people here, not Caucasians. But I agree, we need to keep the language barrier in mind, and I think the OP likely meant Caucasians. I could be wrong, though!
I haven’t read anything about different races and/or ethnicity having a higher risk than any other peoples for diabetes risk. I think it has to do with when you developed diabetes and if you and your spouse have it. Below is the general information I have seen and its pretty consistent. The link is below as well. The chances of you and your wife passing on Type 1 is pretty high since you both have it but many decisions in this world have higher negative odds that are well worth the risk. I would say you need to both be in agreement before moving forward and plan for the potential of having diabetic children but hope for the best that they don’t get it.
“In general, if you are a man with type 1 diabetes, the odds of your child developing diabetes are 1 in 17.
If you are a woman with type 1 diabetes and your child was born
before you were 25, your child’s risk is 1 in 25; if your child was born
after you turned 25, your child’s risk is 1 in 100.
Your child’s risk is doubled if you developed diabetes before age 11.
If both you and your partner have type 1 diabetes, the risk is between 1
in 10 and 1 in 4.” - http://www.diabetes.org/diabetes-basics/genetics-of-diabetes.html1
I have two young children 18 months and 4 years. So far it has not showed up with them. I have been told it’s a higher risk if the father has it and/or both parents have it. I was also told since I didn’t have mine until I was 27 (oldest) and 30 with my youngest it would be a lower chance. Look at it this way at least if you have a child who gets it you will be prepared and know things that can happen and know what to look for. My husband told me that if either child gets it that it’s a blessing that I have it as their mother because I will know what to expect.
Human leukocyte antigen (HLA) encoded susceptibility to develop type 1 diabetes mellitus (T1DM) has been investigated in children from North India. The results revealed significantly increased prevalence of HLA-A26, -B8, and -B50 among patients and strong positive association of the disease with DRB10301 (82.1% vs 13.9%, χ2 = 71.3, odds ratio [OR] = 28.3) and a negative association with DRB102 (χ2 = 12.2, PF = 38.5). HLA-DQB10201 occurred in 96.4% of the patients, whereas the heterodimer DQA10501-DQB10201 was present in 82.1% of patients (60.7% in single dose and 21.4% in double dose) and revealed significant deviation from the healthy controls (χ2 = 74.1, pc = 6.0E-10). In addition to DRB103, positive association was also observed with DRB109 (14.3% vs 1.3%, χ2 = 13.4) and DRB104 (39.3% vs 15.6%, χ2 = 8.39). No HLA association was observed in relation to residual pancreatic β-cell function or associated thyroid autoimmunity. Family analysis revealed involvement of multiple DR3+ve haplotypes with T1DM in North Indian children with A26-B8-DRB103 (25% vs 3.5%, χ2 = 16.9, p = 3.96E-05) and Ax-B50-DRB103 (25% vs 0.7%, χ2 = 44.7, p = 9.88E-11) being the most frequent haplotypes encountered among patients. The classical Caucasian haplotype A1-B8-DRB1*03 was infrequent (7.2%) among the diabetic children. The study highlights the race specificity of HLA association and disease associated HLA haplotypes in T1DM among North Indian Children.
Kanga, U., Vaidyanathan, B., Jaini, R., Menon, P. S., & Mehra, N. K. (2004). HLA haplotypes associated with type 1 diabetes mellitus in North Indian children. Human immunology, 65(1), 47-53.Kanga, U., Vaidyanathan, B., Jaini, R., Menon, P. S., & Mehra, N. K. (2004). HLA haplotypes associated with type 1 diabetes mellitus in North Indian children. Human immunology, 65(1), 47-53.
