I was on Symlin for about 4 months. Had a huge prob with the nausea at the beginning, but after a month or so I started giving square-wave boluses with like 40% at the start and the rest over 2 hours. Honestly, I often noticed that I needed more insulin than usual for some reason once I was on the full type-1 dose of Symlin. Let’s say that normally I’d have taken 8 units for a particular meal, spiked at 200 or so and at two hours ended up at 120 and stayed there. Well, with Symlin I’d take the 8 with a square wave, spike at only 120 (that was so great!) and still be at 115 two hours later. Wonderful, right? But then… then… 4 or 5 hours after a meal I’d end up at 250 or even 300. So I’d end up having to take an additional 3 to 5 units to get that down, so I wasn’t too thrilled. If I’d have been able to stay on it longer, perhaps I would have figured out a better system, but I didn’t have lows, so it really seemed that I needed more insulin. Everyone else said they needed less, so maybe my body is just extremely weird.
I did notice that it decreased my appetite a lot, which was great. I need to lose a lot of weight and I found that very helpful. I had to stop Symlin because my insurance company didn’t consider it necessary and it would have cost me something like $120 a month, which I couldn’t afford. Now I live in Europe, where Symlin is not on the market at all (when I last checked they hadn’t even filed for approval with the EU, so it won’t be available here for a long time).