Matt Bendall shows how long Afrezza can last outside the refrigerator. He’s a Tresiba (Basal) and Afrezza (Bolus) user.
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Please add a disclaimer - Kids Dont try this at home ( or should I say - Dont try this with injectable so called rapid acting )?
Interesting experiment regarding the warm temperature. I think everyone who uses it knows that it is capable of holding bg perfectly flat with a simple high GI thing like a soda. Where it becomes challenging and requires some know-how is with higher complexity meals with significant amounts of fat and protein that change digestive rates significantly. If anyone is posting videos like that I’d be interested to see them… Add a couple slices of pizza or a ribeye steak to that soda and keep it flat for 3 hours, that’d be a lot more impressive to me.
It is capable of keeping bg pretty much perfectly flat for up to two hours for me, pretty much regardless of what I eat… (As long as I have a reasonable ballpark guess as to how long to delay the dose). But then if it’s wearing off while food is still digesting after that, significant spikes can occur… Of course one just adapts and learns to take a follow up dose when they eat slow digesting foods.
Don’t get me wrong, it’s still the best treatment available, I’m just highlighting some realities of it
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Matt has lots of videos documented - he is from the big Island
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“Extreme Thermal Stability”? He considers 80 degrees fahrenheit “extreme”? Lispro’s label indicates it can be stored for up to a month at up to 86 degrees, and that is probably conservative. Afrezza’s label says:
“Room Temperature Storage 25ºC (77ºF), excursions permitted 15-30ºC (59-86ºF)
Sealed (Unopened) Blister Cards + Strips Must be used within 10 days”
Also, it is anecdotal evidence from only one person. How about instead the post from “simon_carter” who posted on “tudiabetes”:
"I spent 4 months backpacking in the Middle East back in 2000-2001, and I was using Humalog and Lantus. My insulin was never refrigerated. Towards the end of the 4 months the Humalog was slightly less effective.
After that, I picked up another batch of insulin from my ‘supply dump’, a mate’s wardrobe in London. Then I spent 6 months backpacking in South East Asia, and my insulin did not degrade noticeably."
That’s pretty darn impressive~ Does that somehow justify claiming that lispro is heat resistant – no!
On top of that, WHY did the afrezza tester BURY the afrezza? From “Research Highlight - Stable analog of insulin needs no refrigeration,” did you know that in Africa:
“They resort to burying their insulin in the ground to protect it from the heat of the day…”
Could that have been the purpose for burying in this “test”? This kind of stuff is simply misleading.
It seemed a little odd to hide/ bury it in some kind of public greenhouse instead of, I dunno, just put it under a lamp or something… He’s an odd duck.
Interesting experiment, regarding the warm temperature.
i never use Afrezza, so i don’t know much, about it,.
Ray, that’s the way he chose to do it, you can certainly do your own experiment and share it too. I always think sharing something like this is cool, hard to knock him for that.
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This is why Afrezza is ideal for use in conjunction with the insulin pump. With the pump giving the proper doses for the person’s basal pattern, that would eliminate all highs due to basal variations. Most pumpers know how to utilize the pump for the digestion of pizza, pasta, etc. So one could give the Afrezza for half the dose and do a square wave bolus for the other half, re pasta. In addition you could add temp basals for periods of time after eating (which we also sometimes used to do). So the pump would take care of the second half of the fatty/protein meal. And, as we all know, even with experience and the best of intentions, 30 percent of the time your previously calculated dosages don’t always work. So for any and all highs, Afrezza cannot be beat. Unfortunately, DD was on a pump for eight years and she will have none of it; sick of being attached. If DD was on a pump, along with Afrezza, from past experience with bolusing for food with a pump, I feel confident she could cover these tricky meals.
Thanks for experimenting. Afrezza needs to be tested scientifically in extreme temperatures because if it is stable in very high temps and can be proven as such no other insulin has achieved superiority in that regard. I’ve always thought, it is a powder, makes sense that you may not have to refrigerate it. Of course, we do refrigerate as per instructions.
I think that depends on what you’re trying to accomplish. Adding a pump wouldn’t have been within my goals— I can accomplish essentially perfect non-diabetic results even with MDI, my assumption is that it would probably be even easier to do so with a pump for me— but what I’m going for is a more simple plan that still yields great results. Others pursue great results by adding more and more complexity to their management, more tools to their toolbox. That’s great if it’s what they’re after, but it’s not for me.