Coincidentally I just put up a page on my blog this morning about how Januvia works. http://diabetesupdate.blogspot.com.
Unfortunately, if you read the hype that is being promoted about this drug, you’ll run into a lot of misinformation. It works for people who respond strongly to a Sulfonylurea drug, which included me for 3 months, but it has some unpleasant side effect, and MOST importantly, there is some evidence that it makes changes to the operation of the immune system which could allow cancers to grow that the body would otherwise be able to fight off.
Melanoma is the cancer that the body appears to fight by using DPP-4, the enzyme that Januvia inhibits. I’m a melanoma survivor so I stopped taking it as soon as I learned that no testing was done to ensure that Januvia wouldn’t promote the growth of any preexisting melanoma cells.
This drug works very poorly for Type 2s who have had diabetes for a while and who do not respond strongly to sulf drugs. It also costs $6 a DAY. The hype being used to sell it is scary, as is the very short 2 year period during which it was tested. It uses a completely new mechanism that involves blocking an enyzme used throughout the body and brain but no testing was done to look at its effects on anything but blood sugar.
It worked extremely well for my blood sugar, but it also after a few months stopped my digestive system cold, gave me horrible sinus headaches, and when I cut myself or tested my fingers it would get all inflammed, which isn’t normal for me. My leucocyte count rose while taking it, too.
Anyway, everything I know about it is on my blog and at http://www.phlaunt.com/diabetes/15332388.php Byetta and Januvia