UPDATE: My first night on U-500 was interesting. I had a couple of mishaps, but they had nothing to do with this insulin. They are all credited to my personal goofiness. Let me explain. I did a pod change with the U-500. I checked my BG after the pod change and it was 108. After my reading, I looked at my PDM and realized that my batteries were really low. I had 2 more AAA's in my house and said, "OK, I'll change the batteries!!" I didn't know that after you change the batteries in them PDM, you have to deactivate your pod. I hadn't had this pod on for 5 minutes and I had to change it out. So, when I put the second pod on, I hit a really bad spot. It REALLY REALLY hurt, when the cannula went it. I'm pretty stubborn and unless it's a burn or a broken bone, pain doesn't bother me that much. I DID NOT want to change out another pod in one night. Although it hurt, I kept the pod on for a few hours. All of a sudden that spot started hurting so bad, I couldn't take it anymore and I had to change pods AGAIN. I checked my BG right after the change and it had gone up to 246. I guess I wasn't getting any insulin while the "huting pod" was in me and my BG just shot up. I didn't get an occlusion failure, but for some reason my sugar was out of whack. Anyway, I tried to bolus and the PDM told me that since there was a time change detected (I had to reset the time and date after I changed the battieries), I had to wait a couple of hours before I could bolus. REALLY??? Anyway, I patiently waited because I didn't want to give myself a shot of anything while pumping the U-500. After my waiting period was over, I was able to give myself the suggested bolus. I checked my BG every 2.5 hrs and bolused until my BG came down to about 135. Hopefully, I won't have anymore issues with my pod today and I can see how the U-500 works out.