What is the distribution per hour of Humalog action?

This Journal of Diabetes Science and Technology paper addresses the issue of insulin’s action over time. Rapid acting analog insulin’s duration is commonly thought to be in the 5-6 hour range.

Here’s a graph from that paper that shows the percent remaining insulin on board (IOB) with different duration assumptions.

Using this chart, if a five-hour duration of insulin action is assumed, here’s the approximate %IOB over five hours and the distribution per hour.

1 hour - 90% IOB or 10% used this hour
2 hours - 70% IOB or 20% used this hour
3 hours - 35% IOB or 35% used this hour
4 hours - 12% IOB or 23% used this hour
5 hours - 0% IOB or 12% used this hour

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