Do you believe a cure for diabetes will ever be found?


#21

I said yes! I hope everyday it will happen. I am a long timer at this 47 very long years and after the first 15 I gave up. Was told the same line we are were, cure in 5 years. My family and I bought it. We volunteered all the time at the local ADA, we did fund raisers and drove family and friends nuts asking to support whatever event we were doing at the time.
And as I got older, I started losing hope. And in losing that hope, I swirled into a deep black hole of depression. Such a struggle when you deal with a chronic condition.
Biggest change came when I moved to San Diego. Got great medical care and found a great organization that works with the mental health side of diabetes. Thank goodness people are starting to get that this disease is mainly mental.
But San Diego also got me into research. There is so much happening here. I have done devices, (pumps, CGM, infusion sets, meters), I’ve done drug studies, mental health studies and my biggest was the ViaCyte stem cell study. I have come away from all the trials with a much better understanding of how trials and the FDA work. It’s going to take a long time. While the stem cell study didn’t work, keep in mind it was just the first one. It was just safe and procedural issues. And sadly the cells didn’t make it. But for me the great thing is we now can make cells that can be beta cells and they can make insulin. Who would have thought back in 1970, that was possible. I was very sad to learn, it didn’t work but it gives me hope. There are very dedicated and passionate doctors and researchers driven to find that cure.
Will there be a cure? I believe there will be! Will I be alive to see that cure? Maybe, but i’m thinking probably not. It’s going to take a very long time. Clinical research moves very slowly. But I will continue to do the best I can with the great tools and drugs that have happened that help us tremendously. I want to be in the best shape possible so when that cure happens, I can get in line with the millions of others to get my cure and I don’t want anything to cause me to maybe get booted out of that cure line due to some complication.
So please don’t give up! Just think about how far we have come. I mean, I could still be testing my urine with my little test tube and eye dropper, taking one injection a day and praying I won’t have another one of those lows that Mom and Dad had to call for an ambulance.
How far we have come! The sky is the limit. And artificial pancreas, here I come until that cure happens!


#22

There are five structural problems in medical research which contribute to the slowness in finding a cure for diabetes.

First, there has been a general stagnation in medical progress since around the 1980s, which has been commented on by a number of experts. This has many reasons, but in large part it has been the result of earlier dramatic progress having been produced by there being so much ‘low hanging fruit,’ that is, easy targets for cures which could readily be developed, so that now only the difficult problems remain, which causes the pace of progress to look comparatively slow.

Second, there is a certain listlessness in the way medical research is done, so that when one researcher finds highly promising results, it is not unusual that absolutely nothing is done to develop this research for another decade or two. In part this is because so many people are doing combined M.D.-Ph.D. programs now, so once they publish some research to get their Ph.D., they just drop their interest in research and go on to pursue a career in the more lucrative branches of medicine. Just the other day I saw a research article which made me think, this is could mean a spectacular improvement in patients’ lives, and then I looked and found it had been published in 1991 and never followed up. Sadly, this is typical.

Third, medical research is so heavily regulated that if there were a cure for cancer developed tomorrow, it would take a good 12 to 16 years for it to proceed through all the required stages of research before it could become available for clinical application. Banting and Best went from finding that insulin worked in a few dogs in October, 1921, and by February, 1922, it was already being tested in human patients, but think of how many people would have died needlessly from diabetes if the modern drug approval process had been in place then.

Fourth, there is enormous conservatism in medicine that resists any innovations, even the good ones. This is in part because those who have established their careers as experts in the old treatments don’t want to be displaced from their comfortable situations by having to learn something new. Also, it is because Big Pharma doesn’t want any non-patentable products to emerge which can cure problems less toxically and less expensively than its own proprietary chemicals, so simple things which work quite well where modern, Western medicine has no answers, such as AST-120, nothing but a modified form of charcoal, to slow the development of renal disease in diabetics, are shut out of the Western market. A medical profession proud of its knowledge asserts that pride by automatically dismissing everything new as quackery, as for example when a famous Ohio clinic for diabetics refused to allow its patients to use insulin until it finally relented in 1926, after killing who knows how many patients by its conservatism. Its excuse had been that if it permitted insulin this would just encourage patients not to adhere to their starvation diet!

Fifth, research toward the development of the atomic bomb was going no where until General Grove was put in charge of it. He came in, cancelled projects that were not going to produce any results and accelerated those that were. He also brought researchers together so that useless, dithering, unfocused, and duplicative efforts would be streamlined to produce the desired development of the bomb in time to have a significant impact on World War II. The problem in medical research is that there are no General Groves, and so the dithering, diffusion of effort, repetition of results, unimaginative continuation of dead-end lines of research, failure to combine results from different researchers to achieve a unifying result, simply continues forever.


#23

Nope. As long as the treatment continues to be a cash cow for pharma there is no chance for a cure.


#24

The first and hardest step in solving a problem is defining a problem. I’ve found that Diabetes defies description - not only in my research, but in my own life.
That being said, I’ll go with the old saw that Diabetes will never be cured as it’s way too profitable.


#25

Sadly…No. Too much money wil be lost if we’re cured or even slightly cured. Think about how many companies, services, etc will be useless or limited in what they pedal. Plus, here’s the big one: if there is a cure it will be so far out of reach for the average Joe. There will ‘guidelines’ you have to meet Iike you have now for pumps and supplies. Wrong insurance…you’re out, too. No insurance…opps, too bad for you, also. Oh, the USA will be the last to approve any cure. :disappointed:

Sorry for being a Debby Downer but I also wrestle with Lupus and there’s very little hope in squishing that beast either. The few drugs available lately are out of reach due to Pharmacy Management tiers.

But, I’m grateful for what tools I do have to manage. I do have hope. There is good out there.


#26

So many patients say a cure will never be found because it will kill the cash cow of all the highly profitable diabetes treatment products on the market now. My heart sinks whenever I see another ad on tv for yet another diabetes treatment product, since each is another nail in the coffin of a cure. Interestingly, patients never think of banding together to refuse to buy any of these gadgets so they can starve the cash cow to death.


#27

We live at a time when many old truisms - things we’ve believed in for years - have been proven wrong and in many cases harmful.
One example was that fat - particularly saturated fat - is bad for you and makes you fat as well as damages your heart. The second was that high cholesterol is a sign of impending heart attacks. The third was that we should eat as many grains and other sources of carbohydrates as possible. A fourth was that damaged brain cells cannot be replenished and that brain injuries are for life. Well all have now been thoroughly discredited. As long as a person is certain to use his or her brain as much as possible following an injury, beta cells will replace the damaged brain cells. Eating as much grains and other carbs as possible is the underlying cause of the current diabetes epidemic. There is no verifiable link between high cholesterol and heart disease. And it is now known that fat does not make you fat, as we as humans are incapable of storing dietary fat as body padding. (Although eating fat may prevent you from losing weight as ingested fat is burned for energy before your body starts burning stored flab.) So it would not surprise me if in our lifetime another of these “truisms”, that Diabetes cannot be cured only managed, may well fall into the same category as the examples above.