New Insulins

Has anyone tried FIASP? It’s a new insulin. My brother’s insurance no longer covers Humalog or Lispro. It has suddenly announced that it does cover a new insulin called Admelog, but the pharmacy can’t get it. So now our choices are FIASP or Novolog. It’s my understanding Novolog is slow acting. It sounds like FIASP is faster acting. Has anyone tried these new insulins? I think people with diabetes are going to have to start using these new insulins.

Your understanding is incorrect. Novolog is a fast-acting insulin. Many patients find no difference between Humalog and Novolog; however, there are some very minor differences that affect a select group of diabetics. I have used both over the years, and there has been virtually no difference between using one or the other. The time to peak after a meal and duration were very slightly different.


Here is a good run down on current insulins

Lots of people shared their experiences with it in this topic:

Did your brother get a letter about a change to their formulary mentioning admelog and fiasp? Those are computer generated and the substitutions are based on drug categories. His doctor can help him choose an insulin that will work for him.

My endo recommended that I switch to Fiasp from Novalog a few years ago. I didn’t notice any difference at all.

Fiasp came out around 2017/2018 in the US. I am one of those that Fiasp just doesn’t work for me. That different chemical make up it has for some reason seems to make a difference in how some of us respond. It’s only a small percentage of us that’s the case though. In the UK, I would gather the government has a deal with Fiasp and pretty much switched everyone to it that uses insulin with a few exceptions. So a majority of people over there use it successfully with no issues and like it as it worked faster than the Novolog that was prevalent before that.

BTW I gather Admelog is very similar to Humalog and in fact Sanofi used Humalog to get it approved.

Both Admelog and Humalog are insulin lispro injections used to control blood sugar (glucose) in patients 3 years and older with type 1 diabetes and adults with type 2 diabetes. Humalog, from Eli Lilly, is the original reference product and Admelog, from Sanofi, is the first rapid-acting, mealtime insulin approved as a “follow-on” product that relied, in part, on the FDA’s finding of safety and effectiveness for Humalog to support approval (approved via 505(b)(2), an abbreviated pathway).

Fiasp is manufactured by Novolog with added B3 to make it work faster.

Fiasp (insulin aspart) is a newer formulation of NovoLog with niacinamide (vitamin B3) added. Niacinamide helps to increase the speed of the initial absorption of insulin, resulting in an onset of appearance in the blood approximately 2.5 minutes after administration.

Some people (myself included) find that Fiasp, used in a T:slim pump, will cause occlusions after only about 2 days. Lumjev (Lilly product) has a similar problem for me. As a result, I use only Humalog/Lispro or Novolog, all of which perform equally for my, very fast, very reliable.

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Again correct Navalog is a fast acting insulin , I can take 2-4 units and Blood glucose levels are dropping in 10-20 minutes

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Hi there - I have used Fiasco in my Omnipod Dash for the past 4-5 yrs. It is fast acting and peaks in 30-45 minutes, depending on what you’re eaten. It has about 4 hours in total from the time you initiate it. As it’s been such a long time for me, I actually do quite like it. Acts quickly and then disappears within 4 hours.

Auto-correct is so funny!


And as many of us T1Ds know, it’s all a big fiasco at the best of times! But yes, have used Fiasp for at least 4 yrs since I started using Omnipod Dash. :slightly_smiling_face:

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Think it’s only been 3 yrs but that’s besides the point.

I was on humalog when Lyumjev came out. I totally see a huge difference. I love Lyumjev. No need to pre bolus before meals. Just dose when served. Recently started on tandem t slim pump and use Lyumjev in pump. Prior to pump was MDI for three years.

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