@Terry4 (& anyone else) I would be interested in your take on my daughter’s experiences.
Dxd at age 11 with T1, with a very strong family history of T2 in both my husband’s family & my own but no known T1. There is also very strong history of autoimmunity in my family (RA, Hashimotos, uveitis, psoriatic arthritis, lupus, MS, Sjogren’s syndrome, scleroderma) & at least 2 cases in my husband’s family. Shortly before dx, she began to develop what we now know are common signs of PCOS. There was no doubt about her T1 dx. She was positive for 3 antibodies.
I think with the multiple autoimmune disorders in my family it’s safe to assume a genetic predisposition. I don’t believe that genetic anomaly cancels out the predisposition to T2. Her former ped endo has been active in researching T2 in children & believes the genetic predisposition to T2 is very much related to her current medical issues & insulin resistance. Despite eating low carb, being physically active & losing the 30+ lbs she gained prior to the PCOS dx, she is still insulin resistant. She takes 2000mg metformin/day & has for 4 years. Her TDD is still above average for her weight & age. He describes her condition as double diabetes, & in his discussions with us, he has stressed that her autoimmunity doesn’t prevent T2 genes from manifesting. Early on, he shared a study of CWDs with a family history of T2 & how their T1 behaves very differently. I’ll try to find it & share, but the difference in opinions even among researchers on whether double diabetes exists interests me.