I started on Toujeo around October 1 and had my dose figured out in a couple weeks: 4 units morning and 4 units evening. In early December I lowered the 4 units evening to 3 units. The last couple weeks, my blood sugars are rising starting after around 5 am, although I started a new pen a few days ago. Before Toujeo I was using Humulin N, and my morning blood sugars did the same thing. I had been pleased that Toujeo kept my blood sugars from rising, but I’m losing my excitement about it.
If my Toujeo pens have been unopened and stored in the refrigerator since I got them October 1, I presume that each one should be good as new when I start it. I’ve been taking insulin for almost 30 years, so I’m not a novice, except with Toujeo. I’m noting the same problem in the late afternoon, as my blood sugar begins to rise several hours after lunch. I can take a shot to lower the late-day rise, but for morning blood sugar, I’m asleep and let it go higher. Does Toujeo lose effectiveness as you get used to it?