I know there are two other T1s here that are taking Afrezza, but I thought for those of you who don't frequent Reddit, Mnkd boards, or Twitter where I post most often that I would make a thread here. Note, that I do not have a CGM :(.
My history is this. Age 28, 5-11, 198lbs. Diagnosed at age 13ish after taking Prednisone for many years for a chronic liver disease. Started insulin therapy due to contradictions for liver disease with the oral meds. I used insulin 1-2 years. Once I stopped the Prednisone, I lost a lot of weight, and no longer needed treatment until last year when typical diabetes symptoms started to show. Against my doctors advice when I was a teen, I started Janumet and Glimepiride for a few months, then stopped due to a hypersensitivity reaction. I am now using Lantus, Humalog, and Afrezza.
My first issue with Afrezza was the cough. I did suffer asthma as a child/teen, but I grew out of it, so to speak. I passed my FEV1 fine, and was prescribed Afrezza the day after. Upon my first inhalation, I coughed quite a few times intermittently over 15 minutes or so. It also made my airway feel slightly constricted, but it wasn't bad enough to need my inhaler that I keep around, that I haven't used in 7+ years.
This issue continued until about 3 days ago. Since then I have had no problems, even after taking 5 cartridges at once.
I am very insulin resistant. I haven't been on insulin long, but my Dr. was comfortable letting me dose myself and report back to him due to my diabetes knowledge, so I discovered that my I:C is 1:4 on average. This number holds true on Afrezza as well. In fact, it might be 1:3 on afrezza, just depending on the meal.
I find that Afrezza controls my levels well the first 2 hours, but at hour 3 I always get a spike. I assume that this is the fat/protein breaking down into glucose at this point that is causing the spike. I will be trying a technique of dosing 15 mins post meal, then again at 2 hours to see if I can mitigate the spike going forward.
If any of you would like to follow my progress, feel free to check my blog https://afrezzapat.wordpress.com, or my twitter @PatOppa. I will also be posting in this thread obviously :).
I hope to be able to provide as much insightful information that I can for you all regarding someone who is very insulin resistant and T2, who eats a moderate carb diet (even though the last week doesn't show that bc I've been testing a lot to see what I can get away with ;))
Disclaimer: I am not a MNKD or SNY investor, but I may throw $500 of MNKD in my pitiful RothIRA before April 15.