@Andrea8 If you hit certain numbers all the time, like if you started dropping to 53 a few times in a row, (who knows how many times it takes) your threshold for feeling that low drops. So if you hit 45 a lot, you would not feel it. Once you stop feeling the lows it becomes more dangerous as you can pass out because you had no awareness you are dropping that low. Plus some people seem to lose awareness of feeling a low easier than others or just because?
The solve is usually to stop dropping low and maintain a higher BG level so your lowest level might be 75 so you start to feel a low at say 75 or above instead of 50.
To second what @Marie20 said with a curious (but true) and certainly longwinded story: When I came to the US (from the UK) I was used to the UK units of BG measurement. I targeted “5”. That was just fine (about 90mg/dL for those who don’t know). In the US, despite having a Chemistry degree from a prestigious university, I got the math wrong; I multiplied by 10, not 18. My bad.
It didn’t make a damn bit of difference until I moved to Oregon, at which point I started doing serious exercise. The trees are really heavy in this State. It was really weird; I kept on going below 50 and feeling, well, “low” (aside; I was perfectly happy, just sort of feeling like maybe I needed something to eat.)
I suspect that has saved my life, a little; from 1992 I ran “low”. I lived in Cubicleland so I was always High. Lack of exercise, excessive amounts of stress.
But, regardless of my mileage, it is certainly possible to adjust to low and to high BG. These days I’m adjusted to something around, maybe, 120mg/dL; that’s what my HbA1c says. I trust my HbA1c because I made it myself and my degree in Chemistry (with a Biochemistry minor) says that I can’t lie to myself in that respect.