I’m just curious if anyone is aware of their genetics when it comes to their diabetes? I took the 23andMe test a few months ago. Other than the ancestral DNA, which was very much what I expected and confirmed some educated guesses I had as well and a few minor surprises, it showed I had none of the diseases or was a carrier for anything they tested for except the double allele H63D for hereditary hemochromatosis. It’s a mutation with low penetrance, so I probably won’t have any problems with it.
I recently downloaded my raw genetic data from 23andMe and uploaded it to Promethease, which is a part of SNPedia [snipedia]. It’s a wiki for SNPs [snips] (single nucleotide polymorphisms). It yielded sooo many surprises, and was well worth the $12 it cost! I have at least 10 different “snips” that I could find related to type 1 diabetes, that it’s not surprising I eventually developed it. My combined risk is at least 30x times that of the general population.
My family is also littered with autoimmune diseases in general, so I’m at an increased risk for other diseases as well, like 5x for Grave’s Disease (mom’s sister had it) and 6x for rheumatoid arthritis (mom’s sister, dad’s sister, my maternal grandfather’s mother) and plenty of other autoimmune disorders.
It intestingly also showed me that I have impaired enzymatic function for breaking down certain drugs, so I need lower doses than would be expected. It’s drugs like Warfarin, Ciclosporin, Amitriptyline (which I actually take as a migraine prophylactic). It also showed that I should stay away from Plavix, because it won’t help me as much and will significantly increase the risk of heart related “incidents”.